INT160440

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 48
Total Number 50
Disease Relevance 20.38
Pain Relevance 7.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crem) DNA binding (Crem)
Anatomy Link Frequency
striatum 2
forebrain 2
hippocampus 2
nucleus accumbens 2
liver 1
Crem (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 115 100.00 Very High Very High Very High
Hippocampus 238 99.68 Very High Very High Very High
Nucleus accumbens 329 99.64 Very High Very High Very High
antidepressant 148 99.34 Very High Very High Very High
Dopamine 195 99.30 Very High Very High Very High
amygdala 108 98.68 Very High Very High Very High
orphanin 74 98.04 Very High Very High Very High
Nerve growth factor 37 97.60 Very High Very High Very High
Pain 30 97.32 Very High Very High Very High
Catecholamine 39 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 530 100.00 Very High Very High Very High
Stress 444 99.98 Very High Very High Very High
Shock 117 99.98 Very High Very High Very High
Status Epilepticus 111 99.98 Very High Very High Very High
Convulsion 370 99.96 Very High Very High Very High
Apoptosis 316 99.56 Very High Very High Very High
Epilepsy 222 99.56 Very High Very High Very High
Targeted Disruption 972 98.36 Very High Very High Very High
Cold Sores 72 97.90 Very High Very High Very High
Herpes Simplex Virus 44 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amphetamine administration increases ICER mRNA levels in the ventral striatum in a dose-dependent manner; this effect diminishes progressively with repeated drug administration [46].
Positive_regulation (increases) of ICER mRNA in striatum
1) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.16 Pain Relevance 0.24
Seizure activity strongly induces ICER.
Positive_regulation (induces) of ICER associated with convulsion
2) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.45 Pain Relevance 0.40
Moreover, ICER mRNA is upregulated not only immediately after fear conditioning training but is also upregulated specifically when mice are presented with the conditioned stimulus (tone or context) 24 h later [21].
Positive_regulation (upregulated) of ICER mRNA associated with anxiety disorder
3) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.46 Pain Relevance 0.33
The disruption of CREB gene results not only in the impairment of long-term memory but also leads to the significant upregulation of several CREM isoforms, ICER in particular [86].
Positive_regulation (upregulation) of ICER
4) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.60 Pain Relevance 0.05
Increased ICER mRNA levels are also detected in the amygdala after fear conditioning training and testing [21].
Positive_regulation (Increased) of ICER mRNA in amygdala associated with anxiety disorder and amygdala
5) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.10 Pain Relevance 0.14
Once induced, however, ICER upregulation lasts longer than the upregulation of other IEGs in the cell (often more than 24 h) [24, 35, 39, 41, 51–54].
Positive_regulation (upregulation) of ICER
6) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.21 Pain Relevance 0.03
Moreover, ICER mRNA is upregulated not only immediately after fear conditioning training but is also upregulated specifically when mice are presented with the conditioned stimulus (tone or context) 24 h later [21].
Positive_regulation (upregulated) of ICER mRNA associated with anxiety disorder
7) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.46 Pain Relevance 0.33
Amphetamine injection or restraint stress increases ICER mRNA levels in the striatum, reaching maximum levels around 3–4 h later followed by slow return to control levels within 12 h [25, 46].
Positive_regulation (increases) of ICER mRNA in striatum associated with stress
8) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.28 Pain Relevance 0
Electroconvulsive shock upregulates ICER mRNA in rat cortex and hippocampus [38], as do kainate-induced seizures [39], prolonged pilocarpine-induced seizures [40], and amygdala kindling stimulation [21].
Positive_regulation (upregulates) of ICER mRNA in cortex associated with convulsion, shock, hippocampus and amygdala
9) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.47 Pain Relevance 0.42
Under normal conditions, stimulation of the cAMP cascade by stress produces a dual effect: first facilitating CRH gene transcription via phospho-CREB, and later inhibiting it via induction of ICER.
Positive_regulation (induction) of ICER associated with stress
10) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.94 Pain Relevance 0.35
While all four ICER isoforms are induced after pro-apoptotic treatment, isoforms (I?
Positive_regulation (induced) of ICER associated with apoptosis
11) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.98 Pain Relevance 0
Studies using different types of stimulation have demonstrated that ICER induction is relatively slow compared to the induction time course of other immediate early genes (IEGs; ICER expression peaks around 2–6 h after stimulation, depending on types of stimulation and cell types).
Positive_regulation (induction) of ICER
12) Confidence 0.60 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.19 Pain Relevance 0.06
The disruption of CREB gene results not only in the impairment of long-term memory but also leads to the significant upregulation of several CREM isoforms, ICER in particular [86].
Positive_regulation (upregulation) of CREM
13) Confidence 0.60 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.59 Pain Relevance 0.05
In the neuroendocrine system, ICER induction by cAMP contributes to a refractory phase during which additional cAMP stimuli fail to elicit a full transcriptional response [106].
Positive_regulation (induction) of ICER
14) Confidence 0.60 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.29 Pain Relevance 0
The apparent discrepancy of the above findings might be due to differences between the effects of constitutive changes in ICER levels (in the case of gene manipulations) and the effects of transient ICER upregulation (in the case of intact systems).
Positive_regulation (upregulation) of ICER
15) Confidence 0.60 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.42 Pain Relevance 0.04
Numerous studies have demonstrated ICER induction in a variety of cell cultures after treatments that increase intracellular cAMP and induce PKA activation [12, 13, 24, 28, 34, 35].
Positive_regulation (induction) of ICER
16) Confidence 0.60 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0 Pain Relevance 0.14
-T cell lineage, and upregulated CREM in the hippocampus and other forebrain regions; in contrast, wild type expression of CREM is predominantly restricted to neuroendocrine neurons [98].
Positive_regulation (upregulated) of CREM in forebrain associated with hippocampus
17) Confidence 0.56 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.57 Pain Relevance 0.19
Antidepressant and amphetamine treatments also upregulate ICER expression [46, 47], as do lithium chloride and nociceptin injections [48–50].
Positive_regulation (upregulate) of ICER associated with antidepressant and orphanin
18) Confidence 0.50 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.49 Pain Relevance 0.42
Another possible explanation is that the effects of whole forebrain (or brain) changes in ICER levels differ from those of region-specific changes in ICER levels.
Positive_regulation (changes) of ICER in brain
19) Confidence 0.50 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.35 Pain Relevance 0.04
The delayed and prolonged time course of ICER induction suggests that, after reaching a sufficient concentration in the nucleus, ICER acts to suppress gene transcription of other IEGs and/or their target late-response genes and eventually switches off the CRE-mediated gene transcription initiated by the original stimuli [1, 4, 18, 25, 26, 32].
Positive_regulation (induction) of ICER in nucleus
20) Confidence 0.46 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.23 Pain Relevance 0.03

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