INT16047

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Context Info
Confidence 0.57
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.27
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
brain 6
blood 2
nerves 2
nucleus 2
renal nerves 2
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 10 100.00 Very High Very High Very High
cocaine 6 99.96 Very High Very High Very High
Morphine 7 99.38 Very High Very High Very High
anesthesia 4 99.16 Very High Very High Very High
Kinase C inhibitor 1 98.42 Very High Very High Very High
Thermal hyperalgesia 5 97.12 Very High Very High Very High
Pain 11 96.16 Very High Very High Very High
allodynia 3 93.76 High High
ischemia 8 92.64 High High
qutenza 2 91.28 High High
Disease Link Frequency Relevance Heat
Injury 4 98.84 Very High Very High Very High
Hyperalgesia 7 97.12 Very High Very High Very High
Pain 7 96.16 Very High Very High Very High
Adult Respiratory Distress Syndrome 8 96.04 Very High Very High Very High
Leukopenia 1 94.64 High High
Pressure Volume 2 Under Development 1 93.88 High High
Neuropathic Pain 17 93.76 High High
Stress 1 93.44 High High
Disease 1 92.68 High High
Cv Unclassified Under Development 8 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, betamethasone reduced the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induced the expression of IL-10 in the brain, all of which correlated with the changes of pain thresholds in rats.
Negative_regulation (reduced) of Positive_regulation (activation) of IL-1beta in brain associated with pain
1) Confidence 0.57 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.92 Pain Relevance 0.88
On the other hand, the activity of renal nerves showed a transient increase which was followed by a long-lasting suppression after injection of rhIL-1 beta (100 pg, i.v.).
Negative_regulation (suppression) of Positive_regulation (injection) of rhIL-1 beta in renal nerves
2) Confidence 0.42 Published 1991 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1787257 Disease Relevance 0 Pain Relevance 0
An i.v. injection of cyclooxygenase inhibitors (6 mg ibuprofen or 20 mg sodium salicylate) suppressed almost completely the rhIL-1 beta (100 pg)-induced activity in adrenal and splenic nerves.
Negative_regulation (suppressed) of Positive_regulation (-induced) of rhIL-1 beta in nerves
3) Confidence 0.42 Published 1991 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1787257 Disease Relevance 0 Pain Relevance 0
In addition, betamethasone reduced the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induced the expression of IL-10 in the brain, all of which correlated with the changes of pain thresholds in rats.
Negative_regulation (reduced) of Positive_regulation (elevation) of IL-1beta in brain associated with pain
4) Confidence 0.42 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.92 Pain Relevance 0.88
Increases in the gastric content of TNF-alpha and IL-1beta after aspirin administration were inhibited by pretreatment with rolipram.
Negative_regulation (inhibited) of Positive_regulation (Increases) of IL-1beta associated with aspirin
5) Confidence 0.42 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 15986861 Disease Relevance 0.36 Pain Relevance 0.48
Serum IL-1beta and IL-6 levels were significantly higher at 2, 4, and 8 hours after LPS injection and were equally suppressed in the laparotomy and laparoscopic groups (P < 0.05).
Negative_regulation (suppressed) of Positive_regulation (levels) of IL-1beta
6) Confidence 0.41 Published 2005 Journal Surg Laparosc Endosc Percutan Tech Section Abstract Doc Link 15956894 Disease Relevance 0.47 Pain Relevance 0.22
Noxious effect of sensory nerves ablation on the pancreas was accompanied by the reduction in pancreatic blood flow and an increase in plasma interleukin-1beta.
Negative_regulation (reduction) of Positive_regulation (increase) of interleukin-1beta in blood
7) Confidence 0.41 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12892840 Disease Relevance 0.83 Pain Relevance 0.36
The elevated TNFalpha, IL-1beta and NF-kappaB in brain were accordingly reduced, while the expression of increased IL-10 were even stimulated after repeated mirtazapine administration.
Negative_regulation (reduced) of Positive_regulation (elevated) of IL-1beta in brain
8) Confidence 0.41 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18248895 Disease Relevance 0.73 Pain Relevance 1.04
Chronic treatment with morphine and ethanol, but not cocaine, attenuates IL-1 beta activation of FOS expression in the rat hypothalamic paraventricular nucleus.
Negative_regulation (attenuates) of Positive_regulation (activation) of IL-1 beta in nucleus associated with cocaine and morphine
9) Confidence 0.38 Published 1995 Journal Adv. Exp. Med. Biol. Section Title Doc Link 7668153 Disease Relevance 0.28 Pain Relevance 0.44
The nonspecific protein kinase inhibitor staurosporine, the specific protein kinase C inhibitor bisindolylmaleimide BIM1, and the protein tyrosine kinase inhibitor genistein reduced the sensitizing effect of IL-1 beta whereas negative controls were ineffective.
Negative_regulation (reduced) of Positive_regulation (effect) of IL-1 beta associated with kinase c inhibitor
10) Confidence 0.36 Published 2002 Journal FASEB J. Section Abstract Doc Link 12374772 Disease Relevance 0.15 Pain Relevance 0.31
In addition, NAC diminished the LPS-induced increases in nitrate/nitrite, MG, TNF-a and IL-1b. 5.
Negative_regulation (diminished) of Positive_regulation (increases) of IL-1b
11) Confidence 0.18 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16445696 Disease Relevance 0.61 Pain Relevance 0.06

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