INT160521

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.75
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
molecular_function (Enpp1) cellular_component (Enpp1) biological_process (Enpp1)
Anatomy Link Frequency
salivary glands 1
Enpp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 8 100.00 Very High Very High Very High
Kinase C 42 96.32 Very High Very High Very High
adenocard 2 94.76 High High
fluoxetine 2 89.04 High High
Osteoarthritis 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Salivary Gland Disease 4 99.72 Very High Very High Very High
Xerostomia 2 98.72 Very High Very High Very High
Disease 3 83.36 Quite High
Chondrocalcinosis 12 78.32 Quite High
Cancer 1 46.48 Quite Low
Cardiovascular Disease 1 46.04 Quite Low
Repression 2 35.68 Quite Low
Aging 3 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Calcification 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Influence of antidepressant drugs on Ecto-nucleotide pyrophosphatase/phosphodiesterases (E-NPPs) from salivary glands of rats.
Regulation (Influence) of NPPs in salivary glands associated with antidepressant and salivary gland disease
1) Confidence 0.26 Published 2009 Journal Arch. Oral Biol. Section Title Doc Link 19473651 Disease Relevance 0.28 Pain Relevance 0.30
These effects were not consequence of transcriptional control of E-NPP1-3 genes.
Regulation (control) of E-NPP1
2) Confidence 0.26 Published 2009 Journal Arch. Oral Biol. Section Abstract Doc Link 19473651 Disease Relevance 0.23 Pain Relevance 0.29
APase = alkaline phosphatase; CPPD = calcium pyrophosphate dihydrate; Ct = threshold cycle; DMEM = Dulbecco's modified Eagle's medium; ePPi = extracellular inorganic pyrophosphate; ERK = extracellular signal-regulated kinase; FCS = fetal calf serum; iPPi = intracellular inorganic pyrophosphate; MAPK = mitogen-activated protein kinase; MEK-1 = mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1; NPPase = nucleotide pyrophosphatase phosphodiesterase; PBS = phosphate-buffered saline; PCR = polymerase chain reaction; PKA = protein kinase A; PKC = protein kinase C; p-NP = para-nitrophenol; p-NPP = para-nitrophenyl phosphate; p-NPTMP = para-nitrophenylthymidine 5'-monophosphate; PPi = inorganic pyrophosphate; siRNA = small interfering RNA; TBS = Tris-buffered saline; TGF-?
Regulation (regulated) of nucleotide pyrophosphatase phosphodiesterase associated with kinase c
3) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0.24 Pain Relevance 0.13

General Comments

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