INT160538

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.08
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Bmp2) extracellular space (Bmp2) growth (Bmp2)
extracellular region (Bmp2) embryo development (Bmp2) protein complex (Bmp2)
Anatomy Link Frequency
chondrocytes 1
bone tissues 1
Bmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 21 98.24 Very High Very High Very High
cytokine 14 94.28 High High
Inflammation 75 93.88 High High
Pain 4 83.20 Quite High
antagonist 8 82.40 Quite High
alcohol 2 78.36 Quite High
backache 2 78.32 Quite High
IPN 3 77.24 Quite High
cINOD 26 56.56 Quite High
Inflammatory response 10 32.88 Quite Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 128 98.12 Very High Very High Very High
Nerve Root Compression 2 96.60 Very High Very High Very High
Cancer 5 95.92 Very High Very High Very High
INFLAMMATION 89 93.88 High High
Gliosis 23 90.16 High High
Osteolysis 1 89.68 High High
Meningioma 2 86.48 High High
Hypesthesia 1 84.28 Quite High
Muscle Weakness 1 83.76 Quite High
Pain 3 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although its use eliminates the risk of harvesting autograft, rhBMP-2 is associated with other complications that raise concern, including a high rate of postoperative radiculitis.
rhBMP-2 Binding (associated) of associated with nerve root compression
1) Confidence 0.40 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19475434 Disease Relevance 0.65 Pain Relevance 0.38
Immunostaining for bone morphogenetic protein-2 and vascular endothelial growth factor was significantly positive in the areas surrounding mature bone tissues in the metaplastic and psammomatous subtypes.
bone morphogenetic protein-2 Binding (Immunostaining) of in bone tissues
2) Confidence 0.25 Published 2009 Journal J Clin Neurosci Section Abstract Doc Link 19766500 Disease Relevance 0.52 Pain Relevance 0.08
We conclude from our results, that a combination of TGFbeta3 and BMP2 promotes better differentiation of mesenchymal stem cells to chondrocytes in our scaffold.
BMP2 Binding (combination) of in chondrocytes
3) Confidence 0.23 Published 2010 Journal J Biomed Mater Res A Section Abstract Doc Link 20128001 Disease Relevance 0 Pain Relevance 0.30
superfamily ligands such as BMP1, BMP2, BMP5, and BMP7 were also expressed in the CNS after KA-induced neurodegeneration (supporting information Table 1).
BMP2 Binding (ligands) of associated with central nervous system
4) Confidence 0.13 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.91 Pain Relevance 0.31

General Comments

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