INT160540

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.43
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PSIP1) endosome (NGF) DNA binding (PSIP1)
cytosol (PSIP1) extracellular space (NGF) signal transduction (NGF)
Anatomy Link Frequency
tendon cells 1
annulus 1
nucleus pulposus 1
NGF (Homo sapiens)
PSIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 28 100.00 Very High Very High Very High
Stimulus evoked pain 4 87.48 High High
Pain 8 86.84 High High
central pain 4 84.88 Quite High
central sensitization 2 62.32 Quite High
cytokine 8 29.28 Quite Low
Root ganglion neuron 2 8.40 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
Lasting pain 4 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 4 87.48 High High
Inflammatory Pain 4 86.80 High High
Tendinopathy 4 86.48 High High
Pain 15 85.84 High High
Nociception 10 83.84 Quite High
Apoptosis 1 51.56 Quite High
Intervertebral Disk Displacement 4 36.56 Quite Low
Ganglion Cysts 2 8.00 Low Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.
NGF Binding (presence) of p75 in tendon cells
1) Confidence 0.29 Published 2009 Journal Histol. Histopathol. Section Title Doc Link 19475530 Disease Relevance 0.46 Pain Relevance 0.17
Gigante and colleagues recently reported the presence of nerve growth factor (NGF) mRNA, the high-affinity tyrosine kinase A receptor and the low-affinity p75 receptor in rounded cells in the disc annulus and nucleus pulposus [5].
NGF Binding (presence) of p75 in nucleus pulposus associated with nerve growth factor
2) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.48 Pain Relevance 0.48
Gigante and colleagues recently reported the presence of nerve growth factor (NGF) mRNA, the high-affinity tyrosine kinase A receptor and the low-affinity p75 receptor in rounded cells in the disc annulus and nucleus pulposus [5].
NGF Binding (presence) of p75 in annulus associated with nerve growth factor
3) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.48 Pain Relevance 0.48

General Comments

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