INT160541

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 1.94
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSIP1) nucleoplasm (PSIP1) extracellular region (BDNF)
nucleolus (PSIP1) nucleus (PSIP1) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
tendon cells 2
tendon 1
BDNF (Homo sapiens)
PSIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 14 93.60 High High
Pain 9 86.84 High High
Neurotransmitter 1 79.44 Quite High
backache 1 74.28 Quite High
nociceptor 1 66.72 Quite High
Lasting pain 2 62.48 Quite High
Inflammation 5 60.32 Quite High
neurotrophin 3 1 45.84 Quite Low
cytokine 4 38.00 Quite Low
central pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 94.08 High High
Tendinopathy 12 86.48 High High
Pain 10 85.84 High High
Nociception 5 79.04 Quite High
Low Back Pain 1 74.28 Quite High
Intervertebral Disk Degeneration 2 71.36 Quite High
INFLAMMATION 5 60.32 Quite High
Cancer 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neurotrophins may play an important role in the tendon through their interaction with the receptor p75 in the tenocytes.
neurotrophin Binding (interaction) of p75 in tendon
1) Confidence 0.49 Published 2009 Journal Histol. Histopathol. Section Abstract Doc Link 19475530 Disease Relevance 0.48 Pain Relevance 0.14
Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.
neurotrophin Binding (presence) of p75 in tendon cells
2) Confidence 0.36 Published 2009 Journal Histol. Histopathol. Section Title Doc Link 19475530 Disease Relevance 0.46 Pain Relevance 0.17
Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.
BDNF Binding (presence) of p75 in tendon cells
3) Confidence 0.36 Published 2009 Journal Histol. Histopathol. Section Title Doc Link 19475530 Disease Relevance 0.46 Pain Relevance 0.17
The p75 receptor is of special interest because it also has the ability to bind to BDNF [20].
BDNF Binding (bind) of p75
4) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.54 Pain Relevance 0.53

General Comments

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