INT160553

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.54
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4B) extracellular region (C4B)
C4B (Homo sapiens)
Pain Link Frequency Relevance Heat
Cluster headache 131 100.00 Very High Very High Very High
headache 48 87.28 High High
Migraine 19 85.20 High High
Pain 34 73.84 Quite High
alcohol 4 70.52 Quite High
Sumatriptan 8 60.80 Quite High
imagery 11 5.00 Very Low Very Low Very Low
Triptan 8 5.00 Very Low Very Low Very Low
Trigeminal neuralgia 5 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cluster Headache 133 100.00 Very High Very High Very High
Disease 22 97.64 Very High Very High Very High
Headache 57 87.28 High High
Paroxysmal Hemicrania 8 84.40 Quite High
Syndrome 3 81.84 Quite High
Eyelid Disease 1 59.88 Quite High
Miosis 4 59.44 Quite High
Ocular Toxicity (including Many Sub-types) 4 59.12 Quite High
Disorders Of The Lacrimal System 4 58.08 Quite High
Pain 29 55.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic factors play a role in CH susceptibility, and a causative role has been suggested for the hypocretin receptor gene.
Regulation (role) of CH associated with cluster headache
1) Confidence 0.14 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2517059 Disease Relevance 1.54 Pain Relevance 1.16
C4-C5 level appears to be affected the most frequently, followed by the C3-C4 level, then C2-C3, C5-C6, and C6-C7.
Regulation (affected) of C4-C5
2) Confidence 0.12 Published 2009 Journal Spine J Section Body Doc Link 19477691 Disease Relevance 0 Pain Relevance 0
It could be argued that the presence of the macaque genome in the set of mammalian species played a key role in ensuring a low average human brick mutation rate as the conservation of the CH nucleotide and flanking sites in the macaque genome (which is closely related to the human genome) might have biased their conservation in the human genome.
Spec (might) Regulation (conservation) of CH
3) Confidence 0.05 Published 2010 Journal Molecular Biology and Evolution Section Body Doc Link PMC2872621 Disease Relevance 0 Pain Relevance 0

General Comments

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