INT160562

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2002
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 49
Total Number 51
Disease Relevance 27.58
Pain Relevance 6.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 28
lymphocytes 5
spleens 2
induced Tregs 2
lymph nodes 1
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 606 100.00 Very High Very High Very High
cytokine 685 99.96 Very High Very High Very High
rheumatoid arthritis 303 99.76 Very High Very High Very High
chemokine 110 99.68 Very High Very High Very High
Arthritis 59 98.88 Very High Very High Very High
Multiple sclerosis 147 98.64 Very High Very High Very High
spinal inflammation 2 97.44 Very High Very High Very High
Central nervous system 87 94.96 High High
abdominal pain 1 92.92 High High
tolerance 108 92.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 636 100.00 Very High Very High Very High
Sprains And Strains 229 100.00 Very High Very High Very High
Pneumonia 130 100.00 Very High Very High Very High
Convulsion 14 99.96 Very High Very High Very High
Chlamydia Infection 141 99.80 Very High Very High Very High
Rheumatoid Arthritis 309 99.76 Very High Very High Very High
Hepatitis C Virus Infection 104 99.76 Very High Very High Very High
Multiple Sclerosis 339 99.68 Very High Very High Very High
Targeted Disruption 223 99.18 Very High Very High Very High
Infection 422 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then assessed whether T cell proliferation plays a role in these observed alterations of CD4+ and CD8+ T cell percentages during the induction and expression of ACAID.
Localization (alterations) of CD4 in T cell
1) Confidence 0.71 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.43 Pain Relevance 0
At 24h after a maximal seizure, CD4(+) and CD8(+) T cells and CD45R(+) B cells appeared in brain, reaching peak numbers at 48 h, but were no longer detected at 7days.
Localization (appeared) of CD4 in B cells associated with convulsion
2) Confidence 0.67 Published 2010 Journal Brain Behav. Immun. Section Abstract Doc Link 19822204 Disease Relevance 1.11 Pain Relevance 0.21
The function of CIITA in Th differentiation was first demonstrated by the observation of increased generation of IL-4 secreting CD4+ T cells in CIITA-/-I-E-transgenic mice (12).
Localization (secreting) of CD4 in T cells associated with targeted disruption
3) Confidence 0.65 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.00 Pain Relevance 0.03
secretion from CD4+ T cells and significant titers of IgG1 and IgG2a WT-1-specific antibodies in HLA-A2 transgenic mouse models.
Localization (secretion) of CD4 in T cells associated with targeted disruption
4) Confidence 0.65 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.49 Pain Relevance 0.04
4. c Cells from above procedure (a) were sorted into CD4+IFN?
Localization (sorted) of CD4
5) Confidence 0.64 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.26 Pain Relevance 0.08
In order to further elucidate the immunomodulatory potential of the B:9-23-induced Tregs, cells from protected donors were isolated, expanded in vitro, separated into CD4+CD25+ and CD4+CD25?
Localization (separated) of CD4 in induced Tregs
6) Confidence 0.64 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.29 Pain Relevance 0.19
In order to further elucidate the immunomodulatory potential of the B:9-23-induced Tregs, cells from protected donors were isolated, expanded in vitro, separated into CD4+CD25+ and CD4+CD25?
Localization (separated) of CD4 in induced Tregs
7) Confidence 0.64 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.29 Pain Relevance 0.19
secreting CD3+CD4+CD28null T cells was analysed by flow cytometry (see above).


Spec (analysed) Localization (secreting) of CD4 in T cells
8) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0.24 Pain Relevance 0.04
CD4+CD28null T cells were identified by morphologically cell-like structures with co-localized immunostainings of CD3, CD4 and CD244, and were manually quantified in independent analyses performed by two persons.
Localization (localized) of CD4 in T cells
9) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0 Pain Relevance 0
Flow cytometric analysis showed that CD45 positive NA-BMCs were positive for CD11b, CD90 and had low amounts of CD4+, CD8+, CD19+, and CD117+ cells.
Localization (amounts) of CD4
10) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.25 Pain Relevance 0.03
As we expected, oxazolone-induced colonic inflammation was aggravated in CIITA-Tg mice (Fig. 3, 4), confirming that the CIITA expression in CD4+ T cells tends to bias CD4+ T cell response into Th2.
Localization (response) of CD4 in T cell associated with inflammation
11) Confidence 0.61 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 1.25 Pain Relevance 0.23
In the patient of HLA-DR1 genotype, HCV-F specific CD4+ T cell response against p65 (TLGPSMAMRAWGGQD) was exhibited by intracellular cytokine staining as shown in Fig. 3A.
Localization (response) of CD4 in T cell associated with hepatitis c virus infection and cytokine
12) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.60 Pain Relevance 0.05
CD28 ligation increases the proliferative response of both CD4+ and CD8+ T cell subsets via these molecular pathways.
Localization (response) of CD4 in T cell
13) Confidence 0.59 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.18 Pain Relevance 0.11
Alternatively, cells activated in the lung by asbestos [e.g., macrophages, dendritic cells (DCs), neutrophils, lymphocytes] may migrate to pulmonary lymph nodes, where they activate CD4+ T cells that are released into the circulation and contribute to atherogenesis.
Localization (released) of CD4 in lung associated with atherosclerosis
14) Confidence 0.58 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535625 Disease Relevance 0.77 Pain Relevance 0.12
Upon viral challenge of vaccinated mice, effector CD4+ and CD8+ lymphocytes were rapidly recruited to the BAL.
Localization (lymphocytes) of CD4 in lymphocytes
15) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.88 Pain Relevance 0.06
In vivo tracking of islet-reactive CD4 T cell elimination during nuclear import inhibitor treatment
Localization (elimination) of CD4 in T cell
16) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 0.27 Pain Relevance 0
We show that PspA199–246 stimulates pneumococcal strain EF3030-primed CD4+ T cells to secrete IL-10.
Localization (secrete) of CD4 in T cells associated with sprains and strains
17) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.98 Pain Relevance 0.16
Under this hypothesis, the population released to the periphery as CD4 or CD8 naïve T cells would be smaller than normal, but already enriched for correcting alleles.
Localization (released) of CD4 in T cells
18) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2567846 Disease Relevance 0.06 Pain Relevance 0
secreting CD4+ T cells have already been shown to be the major protective element against RSV in trials using the sub-unit vaccine BBG2Na [39].
Localization (secreting) of CD4 in T cells associated with respiratory syncytial virus
19) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 1.26 Pain Relevance 0.03
These peptide antigens are subsequently detected by the T cell receptor (TCR) of CD4+ T cells, which proliferate, secrete cytokines, and differentiate into antigen-specific Th effector cells.
Localization (secrete) of CD4 in T cells associated with cytokine
20) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.47 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox