INT160563

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 34
Total Number 37
Disease Relevance 26.53
Pain Relevance 10.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a) extracellular region (Il17a)
Anatomy Link Frequency
T cells 10
Th17 cells 3
fibroblasts 2
helper T cells 2
macrophages 1
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 820 100.00 Very High Very High Very High
Inflammation 671 100.00 Very High Very High Very High
chemokine 99 99.60 Very High Very High Very High
rheumatoid arthritis 856 99.26 Very High Very High Very High
Central nervous system 30 98.80 Very High Very High Very High
Arthritis 200 98.62 Very High Very High Very High
psoriasis 11 97.96 Very High Very High Very High
Neuritis 71 97.00 Very High Very High Very High
Osteoarthritis 55 88.40 High High
Crohn's disease 215 87.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 679 100.00 Very High Very High Very High
Hypoxia 2 100.00 Very High Very High Very High
Rheumatoid Arthritis 860 99.26 Very High Very High Very High
Gastritis 59 99.12 Very High Very High Very High
Central Nervous System Disease 25 98.80 Very High Very High Very High
Arthritis 213 98.62 Very High Very High Very High
Sprains And Strains 256 98.32 Very High Very High Very High
Psoriasis 11 97.96 Very High Very High Very High
Infection 452 97.92 Very High Very High Very High
Colitis 74 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
T cells, a unique subpopulation of T cells with invariant T cell receptor and innate-like properties, has gained much attention lately, especially due to their role in secretion of IL-17A [29].
Localization (secretion) of IL-17A in T cells
1) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.60 Pain Relevance 0
The cytokine IL-23 acts upstream to IL-17 in the IL-17 axis, and it promotes differentiation of Th17 cells and secretion of IL-17A [26].
Localization (secretion) of IL-17A in Th17 cells associated with cytokine
2) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.77 Pain Relevance 0.05
This CD4 T cell subset may be similar to that recently reported to secrete IL-22 but not IL-17 and to be involved in the skin pathophysiology of psoriasis [43,44].
Neg (not) Localization (secrete) of IL-17 in skin associated with psoriasis
3) Confidence 0.72 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.86 Pain Relevance 0.50
Cytokine Expression
   IL-17 is the key cytokine secreted by Th17 cells characteristically [13]. 
Localization (secreted) of IL-17 in Th17 cells associated with cytokine
4) Confidence 0.70 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2786920 Disease Relevance 0.39 Pain Relevance 0.21
Thus, these results indicate that the IL-17A detected in BALF may be mostly attributed to lymphocytes.
Localization (attributed) of IL-17A in lymphocytes
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.74 Pain Relevance 0
This time-point was identified prior to this study, in a time-course experiment, as the optimum for intracellular cytokine measurement of IL-17 and IFN?
Localization (measurement) of IL-17 associated with cytokine
6) Confidence 0.68 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0 Pain Relevance 0.09
Based upon the combined evidence for a role of IL-17 in inflammation, targeting of IL-17 is now being tested as a new therapeutic strategy for the treatment of RA [24].
Localization (targeting) of IL-17 associated with inflammation and rheumatoid arthritis
7) Confidence 0.68 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.88 Pain Relevance 0.47
The Th17 subset of T-cells secrete large amounts of IL17A, which induces the angiogenic factors VEGF and TGF?
Localization (amounts) of IL17A in T-cells
8) Confidence 0.64 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.65 Pain Relevance 0.03
Recently a novel class of T-helper cells, called Th-17 cells, has been found to secrete the pro-inflammatory cytokine IL-17 [7].
Localization (secrete) of IL-17 in T-helper cells associated with inflammation and cytokine
9) Confidence 0.57 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.69 Pain Relevance 0.59
The invasion of extracellular bacteria into the intestinal mucosa triggers the expression of IL-23A, driving Th17 cells to release IL-17A, IL-17F, IL-21, IL-22 and IL-26, which in turn exert a number of proinflammatory effects on intestinal epithelial cells, endothelial cells, macrophages and fibroblasts [10].
Localization (release) of IL-17A in fibroblasts
10) Confidence 0.57 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.61 Pain Relevance 0.25
Indeed, a recent report by Sato et al. has shown the specific importance of the T helper 17 (Th17) subpopulation through secretion of IL17 in bone destruction in rheumatoid arthritis [29].
Localization (secretion) of IL17 associated with rheumatoid arthritis
11) Confidence 0.54 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.19 Pain Relevance 0.05
It has also been shown that IL-17 recruits neutrophils via the release of C-X-C chemokines.
Localization (release) of IL-17 in neutrophils associated with chemokine
12) Confidence 0.40 Published 2009 Journal J. Int. Med. Res. Section Abstract Doc Link 19589271 Disease Relevance 1.32 Pain Relevance 0.33
To our knowledge, this is the first report of an increase in urinary IL-17 release and gene expression in response to intravesical BCG.
Localization (release) of IL-17
13) Confidence 0.40 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.38 Pain Relevance 0.46
Conversely, the majority of CNS mononuclear cells from recipients of IL-23–modulated cells secreted IL-17 (at a 30-fold higher frequency over recipients of IL-12p70–modulated cells).
Localization (secreted) of IL-17 in mononuclear cells associated with central nervous system
14) Confidence 0.30 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.83 Pain Relevance 0.28
T cells, CD8+ T cells, and natural killer (NK) cells have also been shown to secrete IL-17A even in larger amounts as TH17 cells [88–91].
Localization (secrete) of IL-17A in T cells
15) Confidence 0.26 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.73 Pain Relevance 0.09
Two other studies strongly suggest that such effects of TH17 cells seem to be mediated through release of IL-17A and IL-17F [82, 83].
Localization (release) of IL-17A
16) Confidence 0.26 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.69 Pain Relevance 0
, suggesting that the inhibition of IL-17 secretion was unlikely related to a reduced expansion of CD4+ T cells (data not shown).


Localization (secretion) of IL-17 in T cells
17) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2658739 Disease Relevance 0 Pain Relevance 0
RA pathogenesis is characterized by synovial inflammation, secretion of inflammatory cytokines including IL-17 and subsequent joint destruction.
Localization (secretion) of IL-17 in joint associated with inflammation, rheumatoid arthritis and cytokine
18) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 1.76 Pain Relevance 0.81
Although the pathways that drive cytokine release in RA synovium are still undefined, T cells can regulate cytokine secretion by directly releasing IL-17 into the extracellular space or via cellular contacts with synovial macrophages [28, 30].
Localization (releasing) of IL-17 in T cells associated with rheumatoid arthritis and cytokine
19) Confidence 0.23 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2841253 Disease Relevance 1.19 Pain Relevance 0.83
t, IRAK1 and SOCS1in the differentiation of IL-17 producing T cells.
Localization (differentiation) of IL-17 in T cells
20) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.40 Pain Relevance 0.15

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