INT160564

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2011
Negated 3
Speculated 4
Reported most in Body
Documents 64
Total Number 72
Disease Relevance 59.29
Pain Relevance 20.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il22) extracellular region (Il22)
Anatomy Link Frequency
T cells 17
Th17 cells 10
memory T cells 4
blood 4
skin 3
Il22 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1957 100.00 Very High Very High Very High
Inflammation 1364 100.00 Very High Very High Very High
rheumatoid arthritis 2271 99.96 Very High Very High Very High
Crohn's disease 338 99.32 Very High Very High Very High
chemokine 201 99.28 Very High Very High Very High
psoriasis 556 99.16 Very High Very High Very High
Multiple sclerosis 450 98.92 Very High Very High Very High
Inflammatory stimuli 4 98.24 Very High Very High Very High
dexamethasone 9 97.84 Very High Very High Very High
Arthritis 1109 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1398 100.00 Very High Very High Very High
Rheumatoid Arthritis 2280 99.96 Very High Very High Very High
Anaplastic Large Cell Lymphoma 40 99.86 Very High Very High Very High
Cancer 714 99.76 Very High Very High Very High
Burns 378 99.76 Very High Very High Very High
Colitis 62 99.60 Very High Very High Very High
Candida Infection 162 99.54 Very High Very High Very High
Apoptosis 164 99.52 Very High Very High Very High
Disease 1574 99.32 Very High Very High Very High
Necrosis 119 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed increase in expression levels of IL17A, IL17F, IL22 and IL26 and the downstream proinflammatory cytokines IL6 and IL1?
Gene_expression (expression) of IL22 associated with cytokine
1) Confidence 0.55 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.90 Pain Relevance 0.44
IL22 is expressed during chronic inflammation by Th17, natural killer (NK) and Dendritic (DC) cells [37] and acts on IL-22R subunit expressing (intestinal) epithelial cells to induce IL10 and acute phase protein production [38].
Gene_expression (expressed) of IL22 in epithelial cells associated with inflammation
2) Confidence 0.50 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.53 Pain Relevance 0.27
Expression of IL22 during chronic inflammation provides a directional signal from immune cells to epithelium, as immune cells lack IL-22R (Figure 4).
Gene_expression (Expression) of IL22 in immune cells associated with inflammation
3) Confidence 0.43 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.08 Pain Relevance 0.12
In humans STAT3 represents one of the disease loci for Crohn's and inflammatory bowel disease (IBD) [99], and most likely relates to the capacity of Stat3 to promote intestinal barrier function and integrity in response to IL6, IL11 and IL22 exposure.
Gene_expression (exposure) of IL22 in bowel associated with inflammatory bowel disease, inflammation and disease
4) Confidence 0.43 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.09 Pain Relevance 0.12
The expression levels of the Th17 effector cytokines IL17A, IL17F, IL21, IL22 and IL26 were comparable between colonic and ileal control samples (Figure 1B); however, the expression of these cytokines in each individual sample was not consistent.
Gene_expression (expression) of IL22 associated with cytokine
5) Confidence 0.43 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.45 Pain Relevance 0.49
Increased expression of IL17A, IL17F, IL22, IL26, IL21, CCL20 and CCR6 has been found in inflamed colonic tissues of IBD patients [4,14,28-33].
Gene_expression (expression) of IL22 associated with inflammatory bowel disease
6) Confidence 0.43 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.62 Pain Relevance 0.31
The present study assessed the mRNA expression levels of Th17 effector cytokines (IL17A, IL17F, IL21, IL22 and IL26) and genes involved in differentiation (IL6, IL1B, TGFB1, IL23A and STAT3) and recruitment of Th17 cells (CCR6 and CCL20) by quantitative real-time PCR analysis of colonic and ileal biopsies from 22 healthy control subjects, 26 patients with Crohn's disease (CD) and 12 patients with ulcerative colitis (UC).
Gene_expression (expression) of IL22 in Th17 cells associated with inflammatory bowel disease, crohn's disease, disease and cytokine
7) Confidence 0.43 Published 2010 Journal BMC Immunol Section Abstract Doc Link PMC3016394 Disease Relevance 0.88 Pain Relevance 0.34
The expression levels of the Th17 effector cytokines IL17A, IL17F, IL21, IL22 and IL26 were comparable between colonic and ileal control samples (Figure 1B); however, the expression of these cytokines in each individual sample was not consistent.
Gene_expression (expression) of IL22 associated with cytokine
8) Confidence 0.43 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.43 Pain Relevance 0.50
In contrast to the cardiac response, no significant differences were found in those tissues with regard to IL-6, IL-17 and IL-22 levels.


Gene_expression (levels) of IL-22
9) Confidence 0.37 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.53 Pain Relevance 0.14
As shown in figure 2, burn induced an early myocardial inflammation as evidenced by significantly higher (P < 0.05) levels of IL-17, IL-6 and IL-22 in the burn group as compared to the sham animals.
Gene_expression (levels) of IL-22 associated with myocarditis, inflammation and burns
10) Confidence 0.33 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.41 Pain Relevance 0.14
Three hours after injury plasma and tissue (i.e., heart, lung, liver, small intestine) samples were collected and analyzed for the expression of Th-17 cytokine (i.e., IL-6, IL-17, IL-22, IL-23, TGF-?)
Spec (analyzed) Gene_expression (expression) of IL-22 in small intestine associated with injury and cytokine
11) Confidence 0.33 Published 2010 Journal J Inflamm (Lond) Section Abstract Doc Link PMC2918605 Disease Relevance 1.03 Pain Relevance 0.19
In RA, expression of IL-22 was found to be upregulated in synovium and capable of inducing synovial fibroblast proliferation and chemokine production [33].
Gene_expression (expression) of IL-22 in fibroblast associated with chemokine and rheumatoid arthritis
12) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 1.05 Pain Relevance 0.66
IL-22 is produced by Th17 cells [9,30,31] and has been implicated in RA [32,33], whilst IL-23 is thought to be critical for the expansion and survival of Th17 cells.
Gene_expression (produced) of IL-22 in Th17 cells associated with rheumatoid arthritis
13) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.41 Pain Relevance 0.38
IL-22 production by Th17 cells has been shown to be dependent upon IL-23 [38,45,46], thus our observation, which corroborates that of Shen et al. [25], that very few IL-17-producing CD4 T cells express IL-23R provides a potential explanation for the paucity of IL-22-positive IL-17-positive CD4 T cells we observed.
Gene_expression (production) of IL-22 in T cells
14) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.69 Pain Relevance 0.37
Despite the low frequency of IL-17-positive CD4 T cells coexpressing IL-22, the frequency of IL-22-positive CD4 T cells correlated strongly with the frequency of IL-17-producing CD4 T cells in PBMC of RA patients (r = 0.57, P < 0.0004); this correlation was not evident in SFMC (r = 0.35, P = 0.22).
Gene_expression (coexpressing) of IL-22 in T cells associated with rheumatoid arthritis
15) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.72 Pain Relevance 0.36
IL-22 and IL-17 double positive CD4 T cells (Figure 3A) were hardly detectable in PBMC (0.07% (0.02 to 0.30)), or SFMC (0.16% (0.04 to 0.35)) of RA patients and PBMC (0.16% (0.07 to 0.21)) of healthy controls.
Gene_expression (detectable) of IL-22 in T cells associated with rheumatoid arthritis
16) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.58 Pain Relevance 0.39
We examined the frequency of IL-22 and IL-23-receptor (IL-23R) coexpression in IL-17-positive T cells within the SF and peripheral blood of patients with RA.
Gene_expression (coexpression) of IL-22 in blood associated with rheumatoid arthritis
17) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.50 Pain Relevance 0.36
The median percentage of IL-17-positive CD4 T cells coexpressing IL-22 did not significantly differ between SFMC (7.90% (5.57 to 16.23)), RA PBMC (15.13% (3.36 to 26.76)) and PBMC of healthy donors (14.29% (9.37 to 23.85)) (Figure 3B).
Gene_expression (coexpressing) of IL-22 in T cells associated with rheumatoid arthritis
18) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.57 Pain Relevance 0.37
Analysis of IL-22 and IL-23R expression on IL-17-positive CD4 T cells in PBMC and SFMC of patients with RA
Gene_expression (expression) of IL-22 in T cells associated with rheumatoid arthritis
19) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.39 Pain Relevance 0.38
Here, we found that IL-17-producing CD4 T cells in the SF coexpressed very little IL-22.
Neg (little) Gene_expression (coexpressed) of IL-22 in T cells
20) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.97 Pain Relevance 0.59

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