INT160565

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Context Info
Confidence 0.56
First Reported 2009
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 6
Total Number 16
Disease Relevance 10.01
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Il23r)
Anatomy Link Frequency
T cells 6
blood 3
synovial fluid 1
colon 1
Il23r (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1082 99.84 Very High Very High Very High
cytokine 223 93.44 High High
methotrexate 101 90.52 High High
Inflammatory response 2 88.08 High High
psoriasis 127 82.84 Quite High
Inflammation 125 80.64 Quite High
Arthritis 97 78.96 Quite High
spinal inflammation 17 74.60 Quite High
chemokine 12 63.00 Quite High
Crohn's disease 22 57.08 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1084 99.84 Very High Very High Very High
Necrosis 34 98.82 Very High Very High Very High
Cancer 38 98.64 Very High Very High Very High
Colitis 21 97.84 Very High Very High Very High
INFLAMMATION 112 87.72 High High
Disease 218 85.12 High High
Psoriasis 138 82.84 Quite High
Arthritis 81 78.96 Quite High
Low Back Pain 17 74.60 Quite High
Multiple Sclerosis 55 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcription factor ROR-gammat, which controls IL-23R expression, has a functional role, because Rag-/-Rorc-/- mice failed to develop innate colitis.
Gene_expression (expression) of IL-23R associated with colitis
1) Confidence 0.56 Published 2010 Journal Nature Section Abstract Doc Link 20393462 Disease Relevance 0.87 Pain Relevance 0.29
Stimulation of colonic leukocytes with IL-23 induced the production of IL-17 and interferon-gamma exclusively by innate lymphoid cells expressing Thy1, stem cell antigen 1 (SCA-1), retinoic-acid-related orphan receptor (ROR)-gammat and IL-23R, and these cells markedly accumulated in the inflamed colon.
Gene_expression (expressing) of IL-23R in colon
2) Confidence 0.56 Published 2010 Journal Nature Section Abstract Doc Link 20393462 Disease Relevance 0.94 Pain Relevance 0.33
1 and IL-23R subunits.24 Whereas IL-12R?
Gene_expression (subunits.24) of IL-23R
3) Confidence 0.46 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880344 Disease Relevance 0.44 Pain Relevance 0.13
Considering the importance of IL-23 to the development and maintenance of Th17 cells, it is striking that over 90% and 85% of IL-17-producing CD4 T cells in the SF and blood respectively did not express IL-23R.
Neg (not) Gene_expression (express) of IL-23R in T cells
4) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.28 Pain Relevance 0.17
Interestingly, we detected very little expression of IL-23R on IL-17-positive CD4 T cells (Figure 3D, 3E).
Gene_expression (expression) of IL-23R in T cells
5) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.73 Pain Relevance 0.33
Analysis of IL-22 and IL-23R expression on IL-17-positive CD4 T cells in PBMC and SFMC of patients with RA
Gene_expression (expression) of IL-23R in T cells associated with rheumatoid arthritis
6) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.39 Pain Relevance 0.38
We examined the frequency of IL-22 and IL-23-receptor (IL-23R) coexpression in IL-17-positive T cells within the SF and peripheral blood of patients with RA.
Gene_expression (coexpression) of IL-23-receptor in blood associated with rheumatoid arthritis
7) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.50 Pain Relevance 0.36
IL-22 production by Th17 cells has been shown to be dependent upon IL-23 [38,45,46], thus our observation, which corroborates that of Shen et al. [25], that very few IL-17-producing CD4 T cells express IL-23R provides a potential explanation for the paucity of IL-22-positive IL-17-positive CD4 T cells we observed.
Gene_expression (express) of IL-23R in T cells
8) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.58 Pain Relevance 0.29
We examined the frequency of IL-22 and IL-23-receptor (IL-23R) coexpression in IL-17-positive T cells within the SF and peripheral blood of patients with RA.
Gene_expression (coexpression) of IL-23R in blood associated with rheumatoid arthritis
9) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.49 Pain Relevance 0.35
There was a non-significant trend towards a higher frequency of total CD4 T cells expressing IL-23R in RA SFMC (6.28% (3.63 to 9.07)) and RA PBMC (3.65% (2.07 to 5.31)) compared with the PBMC of healthy controls (2.38% (1.68 to 4.74)) (Figure 3F).
Gene_expression (expressing) of IL-23R in T cells associated with rheumatoid arthritis
10) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.75 Pain Relevance 0.34
Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression

Introduction

Gene_expression (expression) of interleukin-23R in synovial fluid associated with necrosis and cancer
11) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Title Doc Link PMC2991017 Disease Relevance 1.11 Pain Relevance 0.40
than their PBMC counterparts, but are not a significant source of IL-22 and do not express IL-23R.
Neg (not) Gene_expression (express) of IL-23R
12) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991017 Disease Relevance 0.99 Pain Relevance 0.32
Th17 cells in synovial fluid produce more TNF than their peripheral blood counterparts, but are not a significant source of IL-22 and do not express IL-23R.
Neg (not) Gene_expression (express) of IL-23R in blood
13) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.74 Pain Relevance 0.38
IL-17-producing CD4 T cells in RA PBMC and SFMC exhibited very little IL-22 or IL-23R coexpression.


Gene_expression (coexpression) of IL-23R in T cells associated with rheumatoid arthritis
14) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991017 Disease Relevance 1.21 Pain Relevance 0.44
All IL-17-producing cells were CD4+CD45RO+; most expressed both CCR6 and CCR4, but only 50% expressed the IL-23 receptor (IL-23R).
Gene_expression (expressed) of IL-23 receptor
15) Confidence 0.06 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19479869 Disease Relevance 0 Pain Relevance 0
All IL-17-producing cells were CD4+CD45RO+; most expressed both CCR6 and CCR4, but only 50% expressed the IL-23 receptor (IL-23R).
Gene_expression (expressed) of IL-23R
16) Confidence 0.06 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19479869 Disease Relevance 0 Pain Relevance 0

General Comments

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