INT160589

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.54
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) signal transducer activity (OPRM1)
Anatomy Link Frequency
macrophage 3
granulocyte 1
IL4 (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
mu opioid receptor 4 95.60 Very High Very High Very High
cytokine 6 88.48 High High
Morphine 2 78.88 Quite High
Opioid 4 78.32 Quite High
depression 2 72.36 Quite High
Analgesic 2 69.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 2 99.20 Very High Very High Very High
Necrosis 2 98.96 Very High Very High Very High
Respiratory Failure 2 72.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this review, the up-regulation of human mu-opioid receptor gene expression in neuronal and immune effector cells by interleukin-1, interleukin-4, interleukin-6 and tumor necrosis factor, as well as its down-regulation by interferon-gamma and granulocyte/macrophage colony-stimulating factor will be summarized along with molecular mechanisms, such as transcription factor-promoter-interactions.
interleukin-4 Positive_regulation (up-regulation) of Gene_expression (expression) of mu-opioid receptor gene in macrophage associated with necrosis, cancer and opioid receptor
1) Confidence 0.13 Published 2009 Journal Front Biosci (Schol Ed) Section Abstract Doc Link 19482692 Disease Relevance 0.27 Pain Relevance 0.68
In this review, the up-regulation of human mu-opioid receptor gene expression in neuronal and immune effector cells by interleukin-1, interleukin-4, interleukin-6 and tumor necrosis factor, as well as its down-regulation by interferon-gamma and granulocyte/macrophage colony-stimulating factor will be summarized along with molecular mechanisms, such as transcription factor-promoter-interactions.
interleukin-4 Positive_regulation (up-regulation) of in granulocyte Gene_expression (expression) of mu-opioid receptor gene in macrophage associated with necrosis, cancer and opioid receptor
2) Confidence 0.04 Published 2009 Journal Front Biosci (Schol Ed) Section Abstract Doc Link 19482692 Disease Relevance 0.27 Pain Relevance 0.68

General Comments

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