INT16060

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.99
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsd) mitochondrion (Ctsd) extracellular space (Ctsd)
lysosome (Ctsd)
Anatomy Link Frequency
plasma 1
skin 1
peripheral nervous system 1
heart 1
Ctsd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 4 99.98 Very High Very High Very High
Inflammation 6 98.12 Very High Very High Very High
cINOD 2 97.88 Very High Very High Very High
Demyelination 1 97.60 Very High Very High Very High
Peripheral nervous system 2 96.76 Very High Very High Very High
alcohol 5 94.16 High High
Sciatic nerve 3 87.76 High High
Neuritis 2 75.00 Quite High
Pain 2 75.00 Quite High
agonist 10 62.20 Quite High
Disease Link Frequency Relevance Heat
Stress 12 99.76 Very High Very High Very High
INFLAMMATION 10 98.12 Very High Very High Very High
Demyelinating Disease 1 97.60 Very High Very High Very High
Diabetes Mellitus 46 96.72 Very High Very High Very High
Obesity 5 95.32 Very High Very High Very High
Injury 1 93.56 High High
Traumatic Shock 2 91.56 High High
Neuropathic Pain 1 91.36 High High
Ocular Toxicity (including Many Sub-types) 1 90.76 High High
Diabetes Complications 1 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To analysis of the obtained data permits concluding that acute stress stimulates activation of the catalytic function of cathepsin D in the heart.
Positive_regulation (activation) of cathepsin D in heart associated with stress
1) Confidence 0.70 Published 1991 Journal Ukr. Biokhim. Zh. Section Abstract Doc Link 1788875 Disease Relevance 0.51 Pain Relevance 0.07
It was found that investigated drugs evoke increased activity of cathepsin D and decreased collagen content (mainly type I) in this tissue.
Spec (investigated) Positive_regulation (increased) of cathepsin D
2) Confidence 0.69 Published 1990 Journal Przegl Dermatol Section Abstract Doc Link 2270295 Disease Relevance 0.17 Pain Relevance 0.12
Although eglin C treatment had no significant effect on the increase in plasma cathepsin D activity, eglin C administration significantly blunted plasma myocardial depressant factor (MDF) accumulation, 54 +/- 3 vs 79 +/- 8 U/ml (p less than 0.02).
Positive_regulation (increase) of cathepsin D in plasma
3) Confidence 0.57 Published 1985 Journal Pharmacol Res Commun Section Abstract Doc Link 4011646 Disease Relevance 0.26 Pain Relevance 0
While transcripts encoding lysosomal enzymes (CTSD, DPP7) were increased, transcripts encoding proteins involved in synaptic vesicular trafficking (RIMBP2, ARL6IP4), transport from the late endosome to the lysosome (ASGR2, RAB9A), and a marker of cholesterol- and sphingolipid-rich lipid raft membrane microdomains involved in clathrin-independent endocytosis (FLOT1) were all decreased.


Positive_regulation (increased) of CTSD
4) Confidence 0.49 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.12 Pain Relevance 0.03
[Increased proteolytic activity of cathepsin D in the skin of rats after administration of various anti-inflammatory drugs].
Positive_regulation (Increased) of cathepsin D in skin associated with aspirin, inflammation and cinod
5) Confidence 0.46 Published 1990 Journal Przegl Dermatol Section Title Doc Link 2270295 Disease Relevance 0.19 Pain Relevance 0.19
These results imply that treatment to limit the infiltration of cathepsin D-positive cells or to reduce the induction or activity of cathepsin D may provide a therapeutic avenue for treating inflammatory demyelination of the peripheral nervous system.
Positive_regulation (induction) of cathepsin D in peripheral nervous system associated with demyelination, peripheral nervous system and inflammation
6) Confidence 0.42 Published 1991 Journal J. Neuroimmunol. Section Abstract Doc Link 1825313 Disease Relevance 0.48 Pain Relevance 0.33
Expression of select genes differentially increased or decreased by microarray analysis, including CYP2K5, VTG, CYP1A, CTSD, and ESR1, was confirmed by qRT-PCR using SYBR Green (Figure 3).
Positive_regulation (increased) of CTSD
7) Confidence 0.15 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2516568 Disease Relevance 0.13 Pain Relevance 0.06
Besides, it has been shown that the alloxan injection causes a significant increase in the activity of several enzymes, such as beta-glucuronidase, N-acetyl-beta-glucosaminidase, lysosomal acid phosphatase, leucine aminopeptidase, and cathepsin D [29].
Positive_regulation (increase) of cathepsin D
8) Confidence 0.10 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC443509 Disease Relevance 1.13 Pain Relevance 0.05

General Comments

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