INT160619

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.96
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cartpt) extracellular region (Cartpt)
Anatomy Link Frequency
spinal 1
Cartpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 151 99.64 Very High Very High Very High
Nucleus accumbens 67 99.48 Very High Very High Very High
antidepressant 114 98.94 Very High Very High Very High
Pain 5 98.32 Very High Very High Very High
sSRI 20 95.60 Very High Very High Very High
depression 84 93.16 High High
Neurotransmitter 14 90.16 High High
Spinal cord 1 87.28 High High
Neuropeptide 6 86.08 High High
alcohol 9 82.48 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 2 98.60 Very High Very High Very High
Aids-related Complex 14 97.28 Very High Very High Very High
Depression 91 93.16 High High
Osteogenic Sarcomas 2 84.92 Quite High
Pain 1 82.48 Quite High
Nociception 3 75.04 Quite High
Recurrence 15 71.36 Quite High
Disease 2 59.76 Quite High
Targeted Disruption 27 53.84 Quite High
Stress 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cocaine- and amphetamine-regulated transcript (CART) peptides have been implicated in spinal pain transmission.
Regulation (regulated) of CART in spinal associated with low back pain, pain and cocaine
1) Confidence 0.45 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19490082 Disease Relevance 0.26 Pain Relevance 0.39
Cocaine- and amphetamine-regulated transcript (CART) has been demonstrated to play a role in regulating the rewarding and reinforcing effects of various drugs of abuse.
Regulation (regulated) of CART associated with cocaine
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2944892 Disease Relevance 0.07 Pain Relevance 0.33
However, there is still a need for animal models of antidepressant drug action that selectively screen and support the involvement of the other peptides namely the CART, calcineurin and AVP.


Regulation (involvement) of CART associated with antidepressant
3) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.36 Pain Relevance 0.55
Category 1 changes in CART, NPY (both increased at 1-day) and Egr1 (decreased at 1-day) in the mPFC were also confirmed by qPCR (Table 2).


Regulation (changes) of CART
4) Confidence 0.07 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.26 Pain Relevance 0.22

General Comments

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