INT160622

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 6.37
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pth1r) plasma membrane (Pth1r) nucleus (Pth1r)
intracellular (Pth1r) cytoplasm (Pth1r) signal transducer activity (Pth1r)
Anatomy Link Frequency
neurons 3
parathyroid 2
Pth1r (Mus musculus)
Pth1r - R150C (1)
Pain Link Frequency Relevance Heat
vagus nerve 414 100.00 Very High Very High Very High
depression 57 98.76 Very High Very High Very High
Glutamate 6 88.00 High High
imagery 4 69.92 Quite High
Pain 4 56.24 Quite High
dexamethasone 10 50.00 Quite Low
addiction 27 5.00 Very Low Very Low Very Low
Action potential 24 5.00 Very Low Very Low Very Low
medulla 18 5.00 Very Low Very Low Very Low
isoflurane 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chondrosarcoma 48 99.92 Very High Very High Very High
Targeted Disruption 8 99.88 Very High Very High Very High
Chondroma 164 99.68 Very High Very High Very High
Depression 57 98.76 Very High Very High Very High
Malignant Neoplastic Disease 56 97.84 Very High Very High Very High
Cancer 40 97.60 Very High Very High Very High
Enchondromatosis 224 97.56 Very High Very High Very High
Cleidocranial Dysplasia 8 83.76 Quite High
Congenital Anomalies 24 57.32 Quite High
Pain 4 56.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of PTHrP, the PTHR1, and their downstream partner Bcl2 may be correlated with the grade of malignancy in chondrosarcoma [16-19].


Gene_expression (Expression) of PTHR1 associated with malignant neoplastic disease and chondrosarcoma
1) Confidence 0.77 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 1.68 Pain Relevance 0.09
Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.
Gene_expression (expressions) of PTHR in parathyroid
2) Confidence 0.75 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
These mice develop ectopic cartilaginous islands similar to those observed in the mice expressing the mutant PTHR1.
Gene_expression (expressing) of mutant PTHR1
3) Confidence 0.52 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 1.62 Pain Relevance 0
A mutant PTHR1 (R150C) was found to be expressed in the enchondromas from two of six unrelated patients with enchondromatosis [10].
Gene_expression (expressed) of mutant PTHR1 (R150C) associated with chondroma and enchondromatosis
4) Confidence 0.52 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 1.06 Pain Relevance 0
Consistent with this conclusion, transgenic mice expressing the mutant PTHR1 under the control of the collagen type II promoter develop tumors that are similar to those observed in human enchondromatosis.
Gene_expression (expressing) of mutant PTHR1 associated with targeted disruption, cancer and enchondromatosis
5) Confidence 0.52 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 1.21 Pain Relevance 0
Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.
Gene_expression (expressions) of parathyroid hormone receptor in parathyroid
6) Confidence 0.32 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
We classified DMX neurons in two groups because: i) these two Gaussian distributions showed the smallest overlap at a PPR value around 0.6; ii) there was a trough at around 0.6 for the distribution of PPR among DMX neurons; iii) the PPR of dm-cNTS neurons never exceeded 0.6.
Gene_expression (distribution) of PPR in neurons associated with vagus nerve
7) Confidence 0.11 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0.21 Pain Relevance 0.69
We classified DMX neurons in two groups because: i) these two Gaussian distributions showed the smallest overlap at a PPR value around 0.6; ii) there was a trough at around 0.6 for the distribution of PPR among DMX neurons; iii) the PPR of dm-cNTS neurons never exceeded 0.6.
Gene_expression (distribution) of PPR in neurons associated with vagus nerve
8) Confidence 0.11 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0.21 Pain Relevance 0.68
In a similar manner to these dm-cNTS neurons [37-40], about half of DMX neurons were classified to "type II" DMX neurons that show short-term depression (PPR < 0.6) and another half were classified as "type I" DMX neurons exhibiting markedly higher PPR values (PPR > 0.6).
Gene_expression (neurons) of PPR in neurons associated with depression and vagus nerve
9) Confidence 0.11 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0.38 Pain Relevance 0.54

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