INT160627

Context Info Confidence 0.22 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.27 Pain Relevance 0.07

transport (Slc8a1) mitochondrion (Slc8a1) plasma membrane (Slc8a1) transmembrane transport (Slc8a1)

Anatomy Link Frequency lumen 1 Slc8a1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 2 71.48 cytokine 2 68.84 dexamethasone 5 50.00 Spinal cord 14 5.00 medulla 8 5.00 midbrain 4 5.00 withdrawal 4 5.00 Hippocampus 4 5.00 backache 2 5.00 member 8 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 8 78.52 Stress 6 69.88 Disease 26 50.32 Motor Neuron Diseases 124 50.00 Repression 6 37.44 Injury 8 17.04 Dementia 30 5.00 Neurodegenerative Disease 16 5.00 Spinal Muscular Atrophy 14 5.00 Fasciculation 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

KEY FINDINGS: Treatment with Dex for 24 h resulted in the inductions of duodenal TRPV6, CaBP-9k and PMCA1b transcripts and renal TRPV5, CaBP-9k, and NCX1 transcripts, while it reduced the transcription of renal TRPV6.

Positive_regulation (inductions) of NCX1

1) Confidence 0.22 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0

In addition, the upregulation of SERCA and the mitochondrial calcium transporters NCX1 and VDAC3, may result in excess calcium being transported out of the mitochondria and into the ER lumen, having the net effect of an increased [Ca2+] in the ER lumen and reduced [Ca2+] in the mitochondria.

Positive_regulation (upregulation) of NCX1 in lumen

2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.27 Pain Relevance 0.03

NCX1 and SERCA were selected for verification by Q-PCR, and were found to be upregulated by 25.75 fold (p<0.0001) and 1.66 fold (p?

Positive_regulation (upregulated) of NCX1

3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0 Pain Relevance 0.04

General Comments

This test has worked.