INT160627

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Context Info
Confidence 0.22
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.27
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc8a1) mitochondrion (Slc8a1) plasma membrane (Slc8a1)
transmembrane transport (Slc8a1)
Anatomy Link Frequency
lumen 1
Slc8a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 71.48 Quite High
cytokine 2 68.84 Quite High
dexamethasone 5 50.00 Quite Low
Spinal cord 14 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 8 78.52 Quite High
Stress 6 69.88 Quite High
Disease 26 50.32 Quite High
Motor Neuron Diseases 124 50.00 Quite Low
Repression 6 37.44 Quite Low
Injury 8 17.04 Low Low
Dementia 30 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 16 5.00 Very Low Very Low Very Low
Spinal Muscular Atrophy 14 5.00 Very Low Very Low Very Low
Fasciculation 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KEY FINDINGS: Treatment with Dex for 24 h resulted in the inductions of duodenal TRPV6, CaBP-9k and PMCA1b transcripts and renal TRPV5, CaBP-9k, and NCX1 transcripts, while it reduced the transcription of renal TRPV6.
Positive_regulation (inductions) of NCX1
1) Confidence 0.22 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
In addition, the upregulation of SERCA and the mitochondrial calcium transporters NCX1 and VDAC3, may result in excess calcium being transported out of the mitochondria and into the ER lumen, having the net effect of an increased [Ca2+] in the ER lumen and reduced [Ca2+] in the mitochondria.
Positive_regulation (upregulation) of NCX1 in lumen
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.27 Pain Relevance 0.03
NCX1 and SERCA were selected for verification by Q-PCR, and were found to be upregulated by 25.75 fold (p<0.0001) and 1.66 fold (p?
Positive_regulation (upregulated) of NCX1
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0 Pain Relevance 0.04

General Comments

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