INT160634

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Context Info
Confidence 0.64
First Reported 2009
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.12
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc8a1) mitochondrion (Slc8a1) plasma membrane (Slc8a1)
transmembrane transport (Slc8a1)
Anatomy Link Frequency
neuronal 1
plasma 1
cardiac myocytes 1
epidermis 1
Slc8a1 (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 1 100.00 Very High Very High Very High
dexamethasone 5 99.42 Very High Very High Very High
Inflammation 9 93.48 High High
dorsal root ganglion 144 93.40 High High
sodium channel 224 91.96 High High
epidural 4 84.16 Quite High
tetrodotoxin 60 79.20 Quite High
fibrosis 4 61.44 Quite High
nociceptor 20 57.36 Quite High
ketamine 4 53.52 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 1 97.16 Very High Very High Very High
Lifespan 4 95.24 Very High Very High Very High
Nociception 32 94.32 High High
INFLAMMATION 9 93.48 High High
Ganglion Cysts 148 93.40 High High
Arrhythmia Under Development 13 74.84 Quite High
Apoptosis 2 65.88 Quite High
Fibrosis 3 61.44 Quite High
Sudden Death 4 49.00 Quite Low
Death 3 40.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcineurin signaling was also shown to up-regulate expression of the Ncx1 gene in cardiac myocytes (44–46).
Gene_expression (expression) of Ncx1 in cardiac myocytes
1) Confidence 0.64 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.20 Pain Relevance 0.03
This study determined the effects of Dex on duodenal and renal expressions of the calcium-processing genes transient receptor potential cation channel, subfamily V, member 5/6 (TRPV5/6), calbindin-D9k/-D28k (CaBP-9k/28k), Na+/Ca2+ exchanger 1 (NCX1), and plasma membrane Ca(2+)-ATPase (PMCA) 1b.
Spec (determined) Gene_expression (expressions) of NCX1 in plasma associated with member 8 and dexamethasone
2) Confidence 0.28 Published 2009 Journal Life Sci. Section Abstract Doc Link 19490920 Disease Relevance 0.19 Pain Relevance 0.37
Consistent with the labeling pattern observed in vivo, NCX1 immunolabeling was not detectable and only extremely low levels of NCX3 reactivity were exhibited in cultured neuronal cell bodies and neurites (data not shown).
Neg (not) Gene_expression (detectable) of NCX1 in neuronal
3) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.46 Pain Relevance 0.29
Three distinct isoforms of NCX (NCX1-3) have been cloned [11-13], and all are expressed in the CNS [14].
Gene_expression (expressed) of NCX1
4) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.32 Pain Relevance 0.64
In epidermis, NCX1 was not detectable in free nerve endings (Figure 2).
Neg (not) Gene_expression (detectable) of NCX1 in epidermis
5) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.79 Pain Relevance 0.39
Na+/Ca2+ exchanger (NCX) isoforms were detected using antibodies against, NCX1 (rabbit; Santa Cruz Biotechnology Inc., Santa Cruz, CA), NCX2 (goat; Santa Cruz Biotechnology Inc.) and NCX3 (rabbit; Lifespan Biosciences, Seattle, WA).
Gene_expression (detected) of NCX1 associated with lifespan
6) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC3002896 Disease Relevance 0.16 Pain Relevance 0.19

General Comments

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