INT160641

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Context Info
Confidence 0.71
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.10
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) cell morphogenesis (Vdr) nucleus (Vdr)
DNA binding (Vdr)
Anatomy Link Frequency
duodenum 1
muscle fiber 1
Vdr (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 3 78.12 Quite High
Inflammation 28 50.00 Quite Low
dexamethasone 5 50.00 Quite Low
fibrosis 3 49.52 Quite Low
cytokine 38 49.08 Quite Low
Calcium channel 2 48.64 Quite Low
tolerance 17 5.00 Very Low Very Low Very Low
Inflammatory response 13 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 3 99.66 Very High Very High Very High
Hypocalcemia 3 99.64 Very High Very High Very High
Hypophosphatemia 3 99.08 Very High Very High Very High
Hypercalcemia 18 98.36 Very High Very High Very High
Targeted Disruption 26 97.40 Very High Very High Very High
Aging 3 84.76 Quite High
Frailty 9 74.40 Quite High
INFLAMMATION 42 50.00 Quite Low
Systemic Lupus Erythematosus 18 50.00 Quite Low
Fibrosis 3 49.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin D receptor (VDR) transcription and protein levels were measured to examine whether VDR expression mediates differential regulation of duodenal TRPV6 between WT and KO mice, but expression and levels of VDR were similar in both genotypes.
Transcription (transcription) of Vitamin D receptor associated with targeted disruption
1) Confidence 0.71 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19777446 Disease Relevance 0.75 Pain Relevance 0.08
Vitamin D receptor (VDR) transcription and protein levels were measured to examine whether VDR expression mediates differential regulation of duodenal TRPV6 between WT and KO mice, but expression and levels of VDR were similar in both genotypes.
Transcription (transcription) of VDR associated with targeted disruption
2) Confidence 0.71 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19777446 Disease Relevance 0.74 Pain Relevance 0.08
Individuals with the C allele have a shorter VDR than those with the T allele, and there is in vitro evidence for enhanced activity of VDR as a transcription factor.
Transcription (transcription) of VDR
3) Confidence 0.69 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.53 Pain Relevance 0
Also, metabolic abnormalities associated with lack of the VDR include hypocalcemia, hypophosphatemia, secondary hyperparathyroidism, bone deformity, and muscle fiber changes.
Neg (lack) Transcription (lack) of VDR in muscle fiber associated with hypocalcemia, congenital anomalies, hypophosphatemia and hypercalcemia
4) Confidence 0.69 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.57 Pain Relevance 0
Individuals with the C allele have a shorter VDR than those with the T allele, and there is in vitro evidence for enhanced activity of VDR as a transcription factor.
Transcription (transcription) of VDR
5) Confidence 0.69 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.51 Pain Relevance 0
Transcripts for VDR and GR in the duodenum increased marginally.
Transcription (Transcripts) of VDR in duodenum
6) Confidence 0.64 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
Interestingly, transcription of vdr was dramatically lower in CD14?
Transcription (transcription) of vdr
7) Confidence 0.28 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0

General Comments

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