INT160642

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Context Info
Confidence 0.62
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.61
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) cell morphogenesis (Vdr) nucleus (Vdr)
DNA binding (Vdr)
Anatomy Link Frequency
parathyroid 4
memory T cells 2
kidney 2
Vdr (Mus musculus)
Pain Link Frequency Relevance Heat
antiepileptic Drug 2 83.44 Quite High
carbamazepine 2 78.64 Quite High
member 8 3 74.48 Quite High
Central nervous system 22 74.24 Quite High
Bile 78 67.56 Quite High
Multiple sclerosis 12 54.72 Quite High
dexamethasone 15 50.00 Quite Low
agonist 18 45.96 Quite Low
Calcium channel 1 45.00 Quite Low
Inflammation 41 14.20 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 46 97.68 Very High Very High Very High
Rickets 16 95.76 Very High Very High Very High
Metabolic Bone Disease 2 81.24 Quite High
Central Nervous System Disease 21 74.24 Quite High
Toxicity 8 61.56 Quite High
Multiple Sclerosis 50 57.36 Quite High
Recurrence 1 47.40 Quite Low
Autoimmune Disease 6 46.96 Quite Low
Disease 24 27.04 Quite Low
Bordatella Infection 2 22.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.
Positive_regulation (increased) of Gene_expression (expressions) of vitamin D receptor in parathyroid
1) Confidence 0.62 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
Vitamin D receptor (VDR) transcription and protein levels were measured to examine whether VDR expression mediates differential regulation of duodenal TRPV6 between WT and KO mice, but expression and levels of VDR were similar in both genotypes.
Spec (whether) Positive_regulation (mediates) of Spec (whether) Gene_expression (expression) of VDR associated with targeted disruption
2) Confidence 0.50 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19777446 Disease Relevance 0.72 Pain Relevance 0.07
Although the expressional changes were weak, duodenal expressions of glucocorticoid receptor (GR), the vitamin D receptor (VDR), and renal expressions of the parathyroid hormone receptor (PTHR) and VDR were increased following 24 h treatment with Dex.
Positive_regulation (increased) of Gene_expression (expressions) of VDR in parathyroid
3) Confidence 0.45 Published 2009 Journal Life Sci. Section Body Doc Link 19490920 Disease Relevance 0 Pain Relevance 0
Thus, these inhibitory effects of 1,25(OH)2D3 are most pronounced in the effector/memory T cells which do express VDR or are mediated by 1,25(OH)2D3-treated DCs.
Positive_regulation (mediated) of Gene_expression (express) of VDR in memory T cells
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.19 Pain Relevance 0.06
Pascussi et al. first suggested that activation of SXR can enhance the expression of the VDR target gene, CYP24, which would increase the catabolism of 1,25(OH)2D3; thereby, leading to drug-induced osteomalacia [Pascussi et al., 2005].
Positive_regulation (enhance) of Gene_expression (expression) of VDR associated with rickets
5) Confidence 0.29 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.44 Pain Relevance 0.08
Although there is also a relatively high level of VDR expression in the small intestine, constitutive CYP24 expression in this tissue is very low or undetectable, in contrast to that in the kidney [Xu et al., 2006].
Positive_regulation (level) of Gene_expression (expression) of VDR in kidney
6) Confidence 0.27 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.26 Pain Relevance 0.21

General Comments

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