INT160670

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Pdia3) endoplasmic reticulum (Pdia3)
Anatomy Link Frequency
reticulum 2
Pdia3 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 1 97.36 Very High Very High Very High
allodynia 1 94.96 High High
Face pain 1 75.00 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
Thalamus 5 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
Thoracotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 94.96 High High
Neuroblastoma 4 84.72 Quite High
Facial Pain 1 75.00 Quite High
Stress 9 70.88 Quite High
Death 14 69.76 Quite High
Prion Diseases 35 62.32 Quite High
Graft Vs Host Disease 1 42.64 Quite Low
Drug Induced Neurotoxicity 1 17.12 Low Low
Apoptosis 4 17.08 Low Low
Disease 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As positive control we used Thapsigargin, an inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase that increases cytoplasmatic calcium concentration [22].
Negative_regulation (inhibitor) of endoplasmic reticulum in reticulum
1) Confidence 0.42 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.53 Pain Relevance 0
AIMS: To evaluate possible effects of the intracerebroventricular (icv) injection of either O-Tricyclo [5.2.1.0(2,6)] dec-9-yl dithiocarbonate potassium salt (D609), a potent antioxidant and inhibitor of phosphatidylcholine specific phospholipase C (PtdCho-PLC) and acid sphingomyelinase (ASMase), or the spin trap/free radical scavenger N-tert-Butyl-alpha-phenylnitrone (PBN), on mechanical allodynia induced by facial carrageenan injection in mice.
Negative_regulation (inhibitor) of PtdCho-PLC associated with allodynia and intracerebroventricular
2) Confidence 0.06 Published 2009 Journal J Orofac Pain Section Abstract Doc Link 19492541 Disease Relevance 0.17 Pain Relevance 0.22
The 78 kDa glucose-regulated protein is generally regarded as an endoplasmic reticulum protein, however, it has been reported to be present in mitochondrial matrix [29].
Negative_regulation (present) of endoplasmic reticulum protein in reticulum
3) Confidence 0.02 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2911678 Disease Relevance 0 Pain Relevance 0

General Comments

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