INT160673

Context Info Confidence 0.49 First Reported 2007 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 16 Total Number 25 Disease Relevance 19.49 Pain Relevance 2.30

transport (Ambp) extracellular region (Ambp) plasma membrane (Ambp) protein maturation (Ambp)

Anatomy Link Frequency bladder 3 urine 2 kidney 2 liver 1 hepatocyte 1 Ambp (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 165 97.00 corticosteroid 1 94.32 aspirin 4 93.20 cINOD 2 92.96 Versed 9 86.16 Inflammatory response 51 85.20 Inflammatory mediators 30 83.92 anesthesia 66 81.12 chemokine 30 69.88 cytokine 57 66.24

Disease Link Frequency Relevance Heat Urinary Tract Infection 913 100.00 Sprains And Strains 851 100.00 Sepsis 27 99.98 Targeted Disruption 206 99.68 Metastasis 1 99.50 Cancer 15 98.20 Apoptosis 22 97.96 Infection 582 97.32 INFLAMMATION 246 97.00 Pressure Volume 2 Under Development 92 93.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Previous studies have shown that BHMT [44] and Cyp2d26 [45] were expressed only liver and kidney, whereas strong expression of AMBP has been observed in developing hepatocyte, pancreas, kidney and gut [46].

Gene_expression (expression) of AMBP in kidney

1) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.14 Pain Relevance 0.03

The present results also suggest that betaine-homocysteine methyltransferase (BHMT), cytochrome P450 family 2 subfamily d polypeptide 26 (Cyp2d26), microglobulin/bikunin precursor (AMBP) and plasminogen are solely expressed in the liver amongst the included organs.

Gene_expression (expressed) of AMBP in liver

2) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.14 Pain Relevance 0

Treatment of patients with severe sepsis using ulinastatin and thymosin alpha1: a prospective, randomized, controlled pilot study.

Gene_expression (using) of ulinastatin associated with sepsis

3) Confidence 0.29 Published 2009 Journal Chin. Med. J. Section Title Doc Link 19493408 Disease Relevance 0.29 Pain Relevance 0.14

A number of genes which have been previously observed to be over-expressed in tumours (Mycs, Clu)[37], tumor suppressors (Patched, Ptch), or otherwise involved in metastasis or DNA repair: bikunin (Ambp)[38], ornithine decarboxylase gene (Odc), Trefoil factor 1 (Tff1)[39], insulin like growth factor (Igf2) [40] and DNA repair protein 1 (Ddb1), were also differentially expressed in NS398 treated infected mice (Figure 3).

Gene_expression (expressed) of Ambp associated with cancer, apoptosis and metastasis

4) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 1.24 Pain Relevance 0

The patients were divided into two groups in a controlled trial: 40 patients were given ulinastatin (ulinastatin group) and 40 patients were given the same volume of normal saline (control group).

Gene_expression (given) of ulinastatin

5) Confidence 0.22 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.58 Pain Relevance 0.23

The patients were divided into two groups in a controlled trial: 40 patients were given ulinastatin (ulinastatin group) and 40 patients were given the same volume of normal saline (control group).

Gene_expression (group) of ulinastatin

6) Confidence 0.22 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.57 Pain Relevance 0.29

The patients were divided into two groups in a controlled trial: 40 patients were given ulinastatin (ulinastatin group) and 40 patients were given the same volume of normal saline (control group).

Gene_expression (group) of ulinastatin

7) Confidence 0.22 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.57 Pain Relevance 0.29

Before the surgical incision, the patients in the ulinastatin group were given 5,000 units/kg of ulinastatin, which were mixed in 100 ml normal saline intravenously over 30 min, and the control group received the same volume of normal saline over the same duration.

Gene_expression (group) of ulinastatin

8) Confidence 0.19 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.17 Pain Relevance 0.31

Previous studies have shown that BHMT [44] and Cyp2d26 [45] were expressed only liver and kidney, whereas strong expression of AMBP has been observed in developing hepatocyte, pancreas, kidney and gut [46].

Gene_expression (expression) of AMBP in hepatocyte

9) Confidence 0.17 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.14 Pain Relevance 0.03

Previous studies have shown that BHMT [44] and Cyp2d26 [45] were expressed only liver and kidney, whereas strong expression of AMBP has been observed in developing hepatocyte, pancreas, kidney and gut [46].

Gene_expression (expression) of AMBP in gut

10) Confidence 0.17 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.14 Pain Relevance 0.03

Previous studies have shown that BHMT [44] and Cyp2d26 [45] were expressed only liver and kidney, whereas strong expression of AMBP has been observed in developing hepatocyte, pancreas, kidney and gut [46].

Gene_expression (expression) of AMBP in pancreas

11) Confidence 0.17 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.14 Pain Relevance 0.03

We show that despite high S100A8/A9 expression in bladder and kidney tissue upon UTI, in this model S100A8/A9 does not contribute to an effective host response against E.

Gene_expression (expression) of UTI in kidney associated with urinary tract infection

12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.08 Pain Relevance 0.12

This study is the first to describe the contribution of S100A8/A9 during (E.coli-induced) UTI using S100A9 KO mice.

Gene_expression (using) of UTI associated with targeted disruption and urinary tract infection

13) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.10 Pain Relevance 0.12

We investigated the contribution of S100A8/A9 in acute urinary tract infection (UTI) by instilling 2 different doses of uropathogenic E. coli transurethrally in wild type (WT) and S100A9 knockout (KO) mice.

Spec (investigated) Gene_expression (contribution) of UTI associated with targeted disruption and urinary tract infection

14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2954806 Disease Relevance 1.47 Pain Relevance 0.19

One of these DAMPs, S100A8/A9 is highly expressed in bladder during complicated U. parvum-induced experimental UTI [17] and in serum of patients with sepsis caused by UTI [40].

Gene_expression (expressed) of UTI in bladder associated with sepsis and urinary tract infection

15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 2.15 Pain Relevance 0.34

We show that despite high S100A8/A9 expression in bladder and kidney tissue upon UTI, in this model S100A8/A9 does not contribute to an effective host response against E.

Gene_expression (expression) of UTI in bladder associated with urinary tract infection

16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.08 Pain Relevance 0.12

Known fitness factors, including iron acquisition and peptide transport systems, were highly expressed during human UTI and support a model in which UPEC replicates rapidly in vivo.

Gene_expression (expressed) of UTI associated with urinary tract infection

17) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2978726 Disease Relevance 0.85 Pain Relevance 0

Relative to expression during human UTI, fimA was upregulated 660- and 640-fold in the murine bladder by strains AL151 and AL371, respectively.

Gene_expression (expression) of UTI in bladder associated with sprains and strains and urinary tract infection

18) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 1.47 Pain Relevance 0

To compare UPEC virulence gene expression in different mammalian hosts, relative expression levels of 46 fitness genes by CFT073 following experimental murine UTI (derived from [4]) were compared to the average relative expression levels (average expression rank) by E. coli patient isolates following human UTI.

Gene_expression (expression) of UTI associated with urinary tract infection

19) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 0.71 Pain Relevance 0.04

Given the abundance of data from our and other laboratories demonstrating the importance of type 1 fimbriae for UTI [27], [28], [29], [77] and positive selection for fimH among UTI isolates [16], a likely explanation for our findings is that expression of these genes may be a transient or regulated event during human infection.

Gene_expression (expression) of UTI in fimbriae associated with infection and urinary tract infection

20) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 1.06 Pain Relevance 0

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