INT160705

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Context Info
Confidence 0.20
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.26
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Enpp3)
Anatomy Link Frequency
lumen 1
Enpp3 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 6 100.00 Very High Very High Very High
cINOD 1 97.52 Very High Very High Very High
Osteoarthritis 30 75.20 Quite High
cytokine 6 57.84 Quite High
depression 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 99.72 Very High Very High Very High
Calcification 92 99.20 Very High Very High Very High
INFLAMMATION 5 96.80 Very High Very High Very High
Adverse Drug Reaction 1 89.04 High High
Parkinson's Disease 2 79.52 Quite High
Osteoarthritis 30 75.20 Quite High
Aging 26 64.32 Quite High
Congenital Anomalies 6 51.12 Quite High
Metabolic Disorder 2 48.12 Quite Low
Chondrocalcinosis 6 42.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of CD63 or CD203c alone or in combination is not sensitive in the diagnosis of nonsteroidal anti-inflammatory drug intolerance.
Positive_regulation (Upregulation) of CD203c associated with aspirin, inflammation and cinod
1) Confidence 0.20 Published 2009 Journal Int. Arch. Allergy Immunol. Section Title Doc Link 19494523 Disease Relevance 0.19 Pain Relevance 0.38
Upregulation of NPP1 but not NPP3 is associated with calcification by chondrocytic cells in situ and in vitro [12, 31].
Positive_regulation (Upregulation) of NPP3 associated with calcification
2) Confidence 0.02 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.76 Pain Relevance 0.13
In cells such as osteoblasts and chondrocytes that normally express NPP1 relatively robustly, NPP1 and NPP3 increase intracellular PPi, suspected to be in large part in the lumen of the ER and Golgi [12, 16, 31].
Positive_regulation (increase) of NPP3 in lumen
3) Confidence 0.01 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.32 Pain Relevance 0.05

General Comments

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