INT160733

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.12
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Hcn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 2 100.00 Very High Very High Very High
Mexiletine 2 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 2 69.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D,L-Sotalol hardly affected the HCN4 channel current.
Regulation (affected) of HCN4
1) Confidence 0.50 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19498275 Disease Relevance 0.05 Pain Relevance 0.13
The inhibitory effects of quinidine, disopyramide, cibenzoline, lidocaine, mexiletine, aprindine, propafenone, flecainide, propranolol, and verapamil on the HCN4 channel current were weak in their therapeutic concentrations, with IC50 values of 78.3, 249, 46.8, 276, 309, 43.7, 14.3, 1700, 50.5, and 44.9 microM, respectively, suggesting that the inhibitory effects on If would be clinically small.
Regulation (effects) of HCN4 associated with mexiletine and lidocaine
2) Confidence 0.37 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19498275 Disease Relevance 0.07 Pain Relevance 0.15

General Comments

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