INT160736

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 10.08
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT7) nucleolus (KRT7) structural molecule activity (KRT7)
nucleus (KRT7) cytoskeleton organization (KRT7) cytoplasm (KRT7)
Anatomy Link Frequency
lymph nodes 1
stomach 1
KRT7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 99.18 Very High Very High Very High
Dysuria 2 84.80 Quite High
imagery 13 79.64 Quite High
palliative 15 63.76 Quite High
Osteoarthritis 2 56.88 Quite High
spastic colon 1 56.24 Quite High
Thoracotomy 1 54.16 Quite High
backache 3 49.00 Quite Low
abdominal pain 5 48.72 Quite Low
Serotonin 1 31.00 Quite Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 20 99.90 Very High Very High Very High
Carcinoma 166 99.84 Very High Very High Very High
Malignant Neoplastic Disease 22 99.62 Very High Very High Very High
Frailty 1 99.40 Very High Very High Very High
INFLAMMATION 5 99.18 Very High Very High Very High
Disease 53 99.00 Very High Very High Very High
Adenocarcinoma 90 98.82 Very High Very High Very High
Injury 12 98.76 Very High Very High Very High
Ependymoma 37 98.72 Very High Very High Very High
Cancer 206 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead we found KRT7 to be strongly repressed in CC (fold-change = -5.1, p-value = 0.0009).
Negative_regulation (repressed) of KRT7 associated with carcinoma
1) Confidence 0.41 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.17 Pain Relevance 0
Immunohistochemically, the tumor cells were stained positive for cytokeratin (CK) AE1/AE3 and partially positive for CK7, but negative for CK20.
Spec (partially) Negative_regulation (positive) of CK7 associated with cancer
2) Confidence 0.30 Published 2009 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19498300 Disease Relevance 0.44 Pain Relevance 0.16
Upon various types of injury such as inflammation or atrophy these cells may additionally switch on K7 and K19, sometimes also K17 (as well as vimentin) and thus express four to five instead of two keratins (Moll et al. 1991).
Negative_regulation (switch) of K7 associated with inflammation, frailty and injury
3) Confidence 0.17 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0.05
Approximately 92% of pancreatic carcinomas are positive for CK7 but can be positive or negative for CK20 (Table 1) [16].
Negative_regulation (positive) of CK7 associated with pancreatic cancer
4) Confidence 0.11 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1802866 Disease Relevance 1.40 Pain Relevance 0
Both our cases were positive for CAM5.2, AE1AE3, EMA and CK7 but negative for CK20.
Negative_regulation (positive) of CK7
5) Confidence 0.06 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2584038 Disease Relevance 1.38 Pain Relevance 0
Immunohistochemical staining of the malignant ascitic cells was positive for CA 125, WT-1, CK7 and ER but negative for CK20, TTF-1, PR, Calretinin and BRST-2.
Negative_regulation (positive) of CK7 associated with malignant neoplastic disease
6) Confidence 0.06 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204026 Disease Relevance 1.23 Pain Relevance 0.15
Immunohistochemistry performed on the stomach and lymph nodes was positive for CK7 and GCDFP (Gross Cystic Disease Fluid Protein) (Figure 3) and negative for CK20, E-cadherin and Her-2.
Negative_regulation (positive) of CK7 in lymph nodes associated with disease
7) Confidence 0.05 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1937002 Disease Relevance 0.97 Pain Relevance 0.06
The histology of the resected specimen was a single poorly differentiated adenocarcinoma (figure 4) (11 mm in maximum dimension) staining strongly positive to TTF-1 and CK7 (figure 5), and negative staining for CK20 and PSA.
Negative_regulation (positive) of CK7 associated with adenocarcinoma
8) Confidence 0.05 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2615008 Disease Relevance 1.01 Pain Relevance 0.07
Immunohistochemistry performed on the stomach and lymph nodes was positive for CK7 and GCDFP (Gross Cystic Disease Fluid Protein) (Figure 3) and negative for CK20, E-cadherin and Her-2.
Negative_regulation (positive) of CK7 in stomach associated with disease
9) Confidence 0.02 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1937002 Disease Relevance 0.97 Pain Relevance 0.06
Immunohistochemistry was positive for CEA and CK-7 and negative for calretinin, CDX-2, CK-20, Muc-2 and Muc-6.
Negative_regulation (positive) of CK-7
10) Confidence 0.01 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2542373 Disease Relevance 1.07 Pain Relevance 0.12

General Comments

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