INT160741

Context Info Confidence 0.44 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.15 Pain Relevance 0.10

mitochondrion (HAX1) nuclear envelope (HAX1) endoplasmic reticulum (HAX1) cytoplasmic membrane-bounded vesicle (HAX1) nucleus (HAX1) cytoplasm (HAX1)

HAX1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 2 100.00

Disease Link Frequency Relevance Heat Apoptosis 1 100.00 Neutrophil Disorders 9 94.88 Disease 1 88.56 Congenital Anomalies 2 75.00 Cognitive Disorder 1 69.04 Epilepsy 1 63.92 Infection 1 5.00 Neutropenia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HAX1 is an anti-apoptotic factor with multiple functions that controls the integrity of the inner mitochondrial membrane potential and interacts with various viruses and cellular proteins.

HAX1 Binding (interacts) of associated with apoptosis

1) Confidence 0.44 Published 2009 Journal No To Hattatsu Section Abstract Doc Link 19928538 Disease Relevance 0.64 Pain Relevance 0

Moreover, recent studies have suggested an association between neurological dysfunction and HAX1 deficiency.

HAX1 Binding (association) of associated with anesthesia

2) Confidence 0.37 Published 2009 Journal Pediatr Blood Cancer Section Abstract Doc Link 19499579 Disease Relevance 0.51 Pain Relevance 0.10

General Comments

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