INT160799

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 9.09
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFALS) extracellular space (IGFALS) extracellular region (IGFALS)
cell adhesion (IGFALS) nucleolus (IGFALS) nucleus (IGFALS)
Anatomy Link Frequency
spinal cord 1
cerebrospinal fluid 1
brain 1
motor neurons 1
neuronal 1
IGFALS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 14 98.96 Very High Very High Very High
Inflammation 16 98.48 Very High Very High Very High
imagery 47 80.56 Quite High
cytokine 2 76.40 Quite High
Neurobehavioral 26 72.28 Quite High
Central nervous system 31 58.12 Quite High
Restless leg syndrome 2 50.00 Quite Low
tolerance 2 50.00 Quite Low
Peripheral nervous system 24 5.00 Very Low Very Low Very Low
Neuritis 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 1018 100.00 Very High Very High Very High
Disease 334 100.00 Very High Very High Very High
Pituitary Cancer 39 100.00 Very High Very High Very High
Neurodegenerative Disease 26 100.00 Very High Very High Very High
Autoimmune Disease 1 100.00 Very High Very High Very High
INFLAMMATION 16 98.48 Very High Very High Very High
Spinal Muscular Atrophy 19 97.44 Very High Very High Very High
Malignant Neoplastic Disease 12 90.80 High High
Toxicity 5 85.08 High High
Targeted Disruption 3 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ALS is a neurodegenerative disease affecting the motor neurons of the spinal cord and brain.
Regulation (affecting) of ALS in brain associated with neurodegenerative disease, motor neuron diseases and spinal cord
1) Confidence 0.29 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC3023358 Disease Relevance 0.92 Pain Relevance 0.25
Continuing work in our laboratory is focused on determining the effects of altered cystatin C concentration/activity on motor neurons in vitro, in order to clarify its potential mechanistic role in ALS pathogenesis.
Regulation (role) of ALS in motor neurons associated with motor neuron diseases
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.92 Pain Relevance 0
The effect of time on longitudinal cystatin C levels in ALS patients with multiple biofluid draws was assessed with SPSS software, using the general linear model for repeated measures.
Regulation (effect) of ALS associated with motor neuron diseases
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.15 Pain Relevance 0
An assessment of the diagnostic parameters of CSF cystatin C concentration revealed that the sensitivity of cystatin C for differentiating ALS patients from disease controls is low for all cutoff values but it displays high levels of specificity and, therefore, cystatin C can only identify a small subset of ALS patients.
Regulation (differentiating) of ALS associated with disease and motor neuron diseases
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 1.08 Pain Relevance 0
However, there were no differences in cystatin C levels between ALS patients and disease controls.
Neg (no) Regulation (differences) of ALS associated with disease and motor neuron diseases
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.50 Pain Relevance 0
However, there were no differences in cystatin C levels between ALS patients and disease controls.
Neg (no) Regulation (controls) of ALS associated with disease and motor neuron diseases
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.44 Pain Relevance 0
We selected these miRNAs, such as miR-125a-5p, miR-125b, miR-524-5p etc, for qRT-PCR verification because these miRNAs were involved in the regulation of pituitary tumor-transforming gene (PTTG), insulin-like growth factor-binding protein 3 (IGFBP-3) and insulin-like growth factor-binding protein complex acid labile subunit chain precursor (IGFALS) based on the miRBase targets bank.
Regulation (regulation) of IGFALS in pituitary associated with pituitary cancer
7) Confidence 0.17 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.17 Pain Relevance 0
Although ALS is not primarily a disorder of autoimmunity or immune dysregulation, there is considerable evidence that inflammatory processes and non-neuronal cells may play a part in pathogenesis of ALS.
Regulation (dysregulation) of ALS in neuronal associated with autoimmune disease, inflammation and motor neuron diseases
8) Confidence 0.15 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 1.27 Pain Relevance 0.21
In six cases, four showed typical changes of ALS and the other two patients had pathological findings of spinal progressive muscular atrophy (SPMA) at autopsy.
Regulation (changes) of ALS in spinal associated with spinal muscular atrophy and motor neuron diseases
9) Confidence 0.14 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2941760 Disease Relevance 1.49 Pain Relevance 0
We used quantitative enzyme-linked immunosorbent assay (ELISA) to assess initial and longitudinal cerebrospinal fluid (CSF) and plasma cystatin C levels in 104 ALS patients and controls.
Regulation (controls) of ALS in cerebrospinal fluid associated with motor neuron diseases
10) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3000338 Disease Relevance 1.17 Pain Relevance 0
ALS is a neurodegenerative disease affecting the motor neurons of the spinal cord and brain.
Regulation (affecting) of ALS in spinal cord associated with neurodegenerative disease, motor neuron diseases and spinal cord
11) Confidence 0.10 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC3023358 Disease Relevance 0.92 Pain Relevance 0.25
Also the subdivision of the IC population according to ankle/brachial index median value showed that values of IGFBP-3 and ALS resulted progressively lower as the severity of the disease increased (F=4.71, P=0.011 for IGFBP-3, and F=12.04, P=0.001, for ALS).
Regulation (values) of ALS in ankle
12) Confidence 0.01 Published 2009 Journal Int Angiol Section Body Doc Link 19506539 Disease Relevance 0.05 Pain Relevance 0

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