INT160814

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Context Info
Confidence 0.07
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 9.61
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6ra) extracellular region (Il6ra) enzyme binding (Il6ra)
Anatomy Link Frequency
joint 2
lung 2
T cells 2
chondrocytes 1
coronary sinus 1
Il6ra (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 381 99.56 Very High Very High Very High
cytokine 196 96.52 Very High Very High Very High
Angina 3 93.60 High High
Central nervous system 49 89.88 High High
Paracetamol 12 82.40 Quite High
epidural 1 81.40 Quite High
rheumatoid arthritis 6 75.00 Quite High
metalloproteinase 6 60.16 Quite High
GABAergic 9 50.00 Quite Low
Arthritis 30 44.56 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 366 99.72 Very High Very High Very High
INFLAMMATION 387 99.56 Very High Very High Very High
Hypoxia 435 99.30 Very High Very High Very High
Disease 125 97.76 Very High Very High Very High
Synovitis 12 97.28 Very High Very High Very High
Cv General 3 Under Development 3 93.60 High High
Hypercalcemia 36 92.56 High High
Multiple Sclerosis 100 90.16 High High
Central Nervous System Disease 42 89.88 High High
Leukemia 6 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data, together with our finding that exposure to chronic hypoxia is associated with increased lung expression of IL-6R and gp-130 mRNA levels, strongly suggest that IL-6 may act partly as an inducer of PA-SMC migration during chronic hypoxia.
Gene_expression (expression) of IL-6R in lung associated with hypoxia
1) Confidence 0.07 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.25 Pain Relevance 0.05
Combining IL-6 and sIL-6R further increased PA-SMC migration (Figure 6a).
Gene_expression (Combining) of sIL-6R
2) Confidence 0.06 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.88 Pain Relevance 0.03
l of FCS-free DMEM containing IL-6, sIL-6-R, or both (100 ng/ml) in the lower chamber.
Gene_expression (containing) of sIL-6-R
3) Confidence 0.06 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0 Pain Relevance 0
These data, together with our finding that exposure to chronic hypoxia is associated with increased lung expression of IL-6R and gp-130 mRNA levels, strongly suggest that IL-6 may act partly as an inducer of PA-SMC migration during chronic hypoxia.
Gene_expression (levels) of IL-6R in lung associated with hypoxia
4) Confidence 0.06 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.25 Pain Relevance 0.03
Transwell migration assays showed that IL-6 (100 ng/ml) or sIL-6R (100 ng/ml) markedly stimulated human PA-SMC migration.
Gene_expression (migration) of sIL-6R
5) Confidence 0.06 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.93 Pain Relevance 0.04
In addition, we studied whether vitamin D3 negatively regulate the expression of IL-6R to inhibit TH17 differentiation but we did not see any significant differences in the IL-6R expression of CD4+ T cells after co-culture with IL-6, TGF-?
Gene_expression (expression) of IL-6R in T cells
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.45 Pain Relevance 0.12
In addition, we studied whether vitamin D3 negatively regulate the expression of IL-6R to inhibit TH17 differentiation but we did not see any significant differences in the IL-6R expression of CD4+ T cells after co-culture with IL-6, TGF-?
Gene_expression (expression) of IL-6R in T cells
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.45 Pain Relevance 0.12
While gp130 is expressed ubiquitously, IL-6R is predominantly expressed on hepatocytes, neutrophils, monocytes/macrophages and some lymphocytes [4].
Gene_expression (expressed) of IL-6R
8) Confidence 0.06 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.41 Pain Relevance 0.11
An alternative signaling pathway involves cleavage of the full-length membrane-bound IL-6R to produce the soluble sIL-6R, which binds to IL-6 and can then activate gp130 signaling directly, even in cells lacking membrane IL-6 receptors(reviewed in [2]).
Gene_expression (produce) of IL-6R in cleavage
9) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.72 Pain Relevance 0.20
Moreover, the sIL-6R:IL-6 ratio is significantly higher in patients with Stage 1 and 2 disease, according to Mallya and Mace [62, 63] assessment of disease activity, compared with patients with Stage 4 disease.
Gene_expression (ratio) of sIL-6R in Stage 4 associated with disease
10) Confidence 0.05 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 1.17 Pain Relevance 0.07
IL-6, in the presence of sIL-6R, induced TIMP-1 mRNA and protein expression in cultured human chondrocytes and synovial fibroblasts [58].
Gene_expression (expression) of sIL-6R in chondrocytes
11) Confidence 0.05 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.63 Pain Relevance 0.03
Elevated levels of IL-6 and sIL-6R in the SF of RA patients can increase the risk of joint destruction and, at the joint level, IL-6/sIL-6R can stimulate pannus development through increased VEGF expression and increase bone resorption as a result of osteoclastogenesis.
Gene_expression (levels) of sIL-6R in joint associated with rheumatoid arthritis and hypercalcemia
12) Confidence 0.05 Published 2010 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2789585 Disease Relevance 1.15 Pain Relevance 0.21
Levels of IL-6 and sIL-6R in SF correlate significantly with local joint measures of chronic synovitis and the severity of joint destruction in patients with RA [60], as does sIL-6R with leucocyte infiltration [61].
Gene_expression (Levels) of sIL-6R in joint associated with rheumatoid arthritis and synovitis
13) Confidence 0.05 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.98 Pain Relevance 0.03
For example, endothelial cells and synoviocytes express gp130 but not IL-6R, and can therefore only respond to IL-6 in the presence of sIL-6R.
Neg (not) Gene_expression (express) of IL-6R in endothelial cells
14) Confidence 0.05 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.21 Pain Relevance 0.03
For example, IL-6 and its specific receptor (IL-6R) are expressed on neurons and glial cells including astrocytes.
Gene_expression (expressed) of IL-6R in astrocytes
15) Confidence 0.01 Published 2003 Journal BMC Pediatr Section Body Doc Link PMC194752 Disease Relevance 0.85 Pain Relevance 0.34
Initial levels of sIL-6R in aorta were significantly higher than in coronary sinus but this difference disappeared after intervention.
Gene_expression (levels) of sIL-6R in coronary sinus
16) Confidence 0.01 Published 2009 Journal Angiology Section Abstract Doc Link 19508977 Disease Relevance 0.25 Pain Relevance 0.31

General Comments

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