INT160828

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 29
Total Number 33
Disease Relevance 13.97
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
liver 4
SK-MEL-28 2
fat 2
B cells 2
brain 2
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 125 100.00 Very High Very High Very High
Inflammatory mediators 20 100.00 Very High Very High Very High
Inflammation 291 99.82 Very High Very High Very High
cytokine 151 99.32 Very High Very High Very High
qutenza 122 99.08 Very High Very High Very High
antagonist 23 97.80 Very High Very High Very High
Central nervous system 51 95.92 Very High Very High Very High
fibrosis 83 95.64 Very High Very High Very High
Paracetamol 11 95.18 Very High Very High Very High
Nicotine 80 94.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 340 100.00 Very High Very High Very High
Toxicity 63 100.00 Very High Very High Very High
Pressure And Volume Under Development 31 100.00 Very High Very High Very High
Brain Injury 53 99.78 Very High Very High Very High
Reperfusion Injury 99 99.24 Very High Very High Very High
Skin Cancer 8 98.92 Very High Very High Very High
Cv Unclassified Under Development 254 98.88 Very High Very High Very High
Lung Injury 16 98.56 Very High Very High Very High
Myocardial Stunning 4 98.24 Very High Very High Very High
Insulin Resistance 119 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant increases in ROS production do not occur in the present study until 30 minutes since ROS levels in cells are tightly regulated.
Regulation (regulated) of Gene_expression (levels) of ROS
1) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.33 Pain Relevance 0.55
In some experiments, ROS scavenger PBN was applied for 90 minutes before capsaicin stimulation, or TRPV1 antagonist capsazepine (10 ?
Regulation (applied) of Gene_expression (scavenger PBN) of ROS associated with qutenza and antagonist
2) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.25 Pain Relevance 0.45
It was also found that APAP selectively caused escalation in reactive oxygen species (ROS) formation and intracellular GSH (ICG) depletion in melanocytic human SK-MEL-28 and murine B16-F0 melanoma cells that express functional tyrosinase whereas it lacked significant effects on ROS formation and ICG in amelanotic C32 melanoma cells that do not express functional tyrosinase.
Regulation (effects) of Gene_expression (formation) of ROS in SK-MEL-28 associated with paracetamol and skin cancer
3) Confidence 0.13 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19513568 Disease Relevance 1.34 Pain Relevance 0.78
Thus, whereas we cannot exclude the possibility that the reduction of ROS in liver altered peripheral insulin sensitivity, it is likely that the improvement in glucose level following reduction of ROS in the liver is mainly caused by reduced expression of gluconeogenic genes.
Regulation (altered) of Gene_expression (reduction) of ROS in liver
4) Confidence 0.13 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.59 Pain Relevance 0
However, we cannot rule out that another antioxidant mechanism could also have controlled the ROS production in response to brain GLP-1 signaling.


Regulation (controlled) of Gene_expression (production) of ROS in brain
5) Confidence 0.13 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.38 Pain Relevance 0.24
It is of interest to examine the effect of the cholinergic agonists on ROS production and the biochemical signaling in hepatic IR.
Spec (examine) Regulation (effect) of Gene_expression (production) of ROS associated with agonist
6) Confidence 0.12 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.29 Pain Relevance 0.44
Image analysis at the ROIs demonstrated that ROS levels are significantly increased in hyperglycemic mice as compared to the controls and that these levels normalized back to control levels in STZ-treated SOD2 overexpressing mice, Figure 3B.
Regulation (control) of Gene_expression (overexpressing) of ROS
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.23 Pain Relevance 0
Method of ROS exposure
Regulation (Method) of Gene_expression (exposure) of ROS
8) Confidence 0.12 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2926425 Disease Relevance 0.08 Pain Relevance 0
Unlike antioxidant compounds, which nonspecifically target all ROS sources in the tissue, knocking out the p47phox subunit of the NADPH oxidase complex shuts down only the main pathway of phagocytic ROS production.
Regulation (target) of Gene_expression (sources) of ROS
9) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.69 Pain Relevance 0.35
13) AD: performed ROS and ALDH-2 measurements, was involved in drafting and interpretation and has made substantial contributions to conception and design of the study of data
Regulation (performed) of Gene_expression (measurements) of ROS
10) Confidence 0.09 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0 Pain Relevance 0
Vitamin C decreased intracellular ROS levels in activated B cells
Regulation (intracellular) of Gene_expression (levels) of ROS in B cells
11) Confidence 0.08 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.14 Pain Relevance 0
Measurement of intracellular ROS levels
Regulation (intracellular) of Gene_expression (levels) of ROS
12) Confidence 0.08 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.12 Pain Relevance 0
Measurement of intracellular ROS levels
Regulation (Measurement) of Gene_expression (levels) of ROS
13) Confidence 0.08 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.12 Pain Relevance 0
The tissue ROS level in each organ depends on the production and elimination of ROS.
Regulation (depends) of Gene_expression (production) of ROS
14) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.50 Pain Relevance 0.04
induced ROS production in astrocytes is postulated to be a consequence of the loss of mitochondrial membrane potential and glutathione depletion; however, exactly how fA?
Regulation (astrocytes) of Gene_expression (production) of ROS in astrocytes
15) Confidence 0.08 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1637099 Disease Relevance 0.14 Pain Relevance 0
Mitochondria are involved both in the production of ROS and as targets for the damaging action of both ROS and calcium [1,3,9,26].
Regulation (targets) of Gene_expression (action) of ROS
16) Confidence 0.06 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.53 Pain Relevance 0
Mitochondria are involved both in the production of ROS and as targets for the damaging action of both ROS and calcium [1,3,9,26].
Regulation (involved) of Gene_expression (production) of ROS
17) Confidence 0.06 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.52 Pain Relevance 0
Whether cholinergic agonist treatment has any effect on ROS generation is of interest.
Spec (Whether) Regulation (effect) of Gene_expression (generation) of ROS associated with agonist
18) Confidence 0.05 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.70 Pain Relevance 0.32
Influence of Fe2O3 NPs on intracellular ROS formation
Regulation (intracellular) of Gene_expression (formation) of ROS
19) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0
Influence of TiO2 NPs on intracellular ROS formation
Regulation (intracellular) of Gene_expression (formation) of ROS
20) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0

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