INT160830

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.37
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Siglece) cell adhesion (Siglece)
Anatomy Link Frequency
MIs 1
eosinophils 1
patella 1
T cells 1
blood cell 1
Siglece (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 113 99.90 Very High Very High Very High
Infliximab 20 99.48 Very High Very High Very High
cytokine 64 97.28 Very High Very High Very High
Etanercept 14 72.48 Quite High
Bioavailability 62 66.76 Quite High
chemokine 14 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
corticosteroid 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 104 99.90 Very High Very High Very High
Apoptosis 113 99.84 Very High Very High Very High
Targeted Disruption 8 99.42 Very High Very High Very High
Mycobacterial Infection 132 83.84 Quite High
Injury 4 83.28 Quite High
Death 38 67.12 Quite High
Disease Progression 2 64.12 Quite High
Infection 161 63.36 Quite High
Parkinson's Disease 1 53.96 Quite High
Asthma 66 37.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mIS can be used efficiently for evaluating an acquired patella baja in radiographs performed in different, not standardized, conditions.


Gene_expression (used) of mIS in patella
1) Confidence 0.39 Published 2009 Journal Orthopade Section Body Doc Link 19513692 Disease Relevance 0 Pain Relevance 0
Peripheral blood cell counts and total serum immunoglobulin E levels
Gene_expression (levels) of serum immunoglobulin E in blood cell
2) Confidence 0.36 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.39 Pain Relevance 0.20
In sham sensitised animals (Alum only), the baseline levels of total serum immunoglobulin E were similar in female (1.8 ± 0.5 ?
Gene_expression (levels) of serum immunoglobulin E
3) Confidence 0.36 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.33 Pain Relevance 0.16
Using IL-5 transgenic mice and Northern blotting, Siglec-E, -F and -G were all expressed at the mRNA level in mouse eosinophils, but patterns of expression were markedly increased in IL-5 transgenic mice only for Siglec-F and Siglec-G.132 Ultimately, it was not until antibodies were generated that this issue was completely resolved, and it is now clear that Siglec-G is expressed on B lymphocytes133 while Siglec-F is most prominently expressed by mouse eosinophils and is considered the closest functional paralog to Siglec-8.134
Gene_expression (expressed) of Siglec-E in eosinophils associated with targeted disruption
4) Confidence 0.15 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.81 Pain Relevance 0.12
Further, due to the nature of its interaction with tmTNF, infliximab induces apoptosis in TNF-producing cells (including MIs and MAs, CD4+ and CD8+ T cells) via a caspase-dependent pathway [52].
Gene_expression (producing) of MIs in T cells associated with infliximab and apoptosis
5) Confidence 0.03 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.10 Pain Relevance 0.27
During latency, TNF levels (Figure 1E) are on the order of 0.12 pg/mL (limited inflammation) as levels of MIs and MAs (activated microphages) are relatively low (and these are major TNF producers).
Gene_expression (levels) of MIs in MIs associated with inflammation
6) Confidence 0.03 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.74 Pain Relevance 0.11

General Comments

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