INT160879

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC, DECR1) cytoplasm (POMC, DECR1) mitochondrion (DECR1)
cell-cell signaling (POMC) extracellular space (POMC) generation of precursor metabolites and energy (POMC)
Anatomy Link Frequency
embryonic kidney 1
POMC (Homo sapiens)
DECR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 1 100.00 Very High Very High Very High
agonist 6 99.72 Very High Very High Very High
Morphine 2 94.36 High High
Buprenorphine 1 93.96 High High
Oxycodone 1 92.60 High High
Opioid 2 89.08 High High
opioid receptor 3 75.00 Quite High
Enkephalin 1 63.76 Quite High
Disease Link Frequency Relevance Heat
Stress 1 77.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrate that receptor-internalizing agonists (like DAMGO, beta-endorphin, methadone, piritramide, fentanyl, sufentanil, and etonitazene) strongly induce NADH/NADPH-mediated ROS synthesis via PLD-dependent signaling pathways, whereas agonists that do not induce MOPr endocytosis and PLD2 activation (like morphine, buprenorphine, hydromorphone, and oxycodone) failed to activate ROS synthesis in transfected human embryonic kidney 293 cells.
beta-endorphin Positive_regulation (induce) of NADPH in embryonic kidney associated with oxycodone, agonist, methadone, buprenorphine and morphine
1) Confidence 0.04 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19519662 Disease Relevance 0.08 Pain Relevance 1.02

General Comments

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