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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pld2) plasma membrane (Pld2) nucleus (Pld2)
signal transducer activity (Oprm1)
Oprm1 (Rattus norvegicus)
Pld2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 6 100.00 Very High Very High Very High
opioid receptor 3 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
Morphine 2 96.84 Very High Very High Very High
Opioid 2 53.76 Quite High
methadone 1 30.16 Quite Low
Buprenorphine 1 25.00 Low Low
Oxycodone 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 1 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently shown that the activation of the rat mu-opioid receptor (MOPr, also termed MOR1) by the mu-agonist [D-Ala(2), Me Phe(4), Glyol(5)]enkephalin (DAMGO) leads to an increase in phospholipase D2 (PLD2) activity and an induction of receptor endocytosis, whereas the agonist morphine which does not induce opioid receptor endocytosis fails to activate PLD2.
Positive_regulation (activation) of mu-opioid receptor Positive_regulation (leads) of Positive_regulation (increase) of phospholipase D2 associated with agonist, enkephalin, opioid receptor and morphine
1) Confidence 0.05 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19519662 Disease Relevance 0.08 Pain Relevance 0.48

General Comments

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