INT160885

Context Info Confidence 0.18 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.84

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)

ROS1 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 2 99.44 agonist 6 99.22 Oxycodone 1 93.48 Buprenorphine 1 92.28 Morphine 2 91.68 methadone 1 82.52 opioid receptor 3 75.00 Enkephalin 1 45.28

Disease Link Frequency Relevance Heat Stress 1 59.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These findings indicate that the agonist-selective PLD2 activation plays a key role in the regulation of NADH/NADPH-mediated ROS formation by opioids.

Positive_regulation (role) of Regulation (regulation) of ROS associated with agonist and opioid

1) Confidence 0.18 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19519662 Disease Relevance 0.06 Pain Relevance 0.84

General Comments

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