INT16090

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Context Info
Confidence 0.36
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.51
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpb1) extracellular region (Cpb1) cellular_component (Cpb1)
biological_process (Cpb1)
Anatomy Link Frequency
blood 1
Cpb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 5 75.00 Quite High
bradykinin 1 75.00 Quite High
metalloproteinase 1 56.44 Quite High
isoflurane 4 24.32 Low Low
Bile 4 11.28 Low Low
Bioavailability 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Ultiva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 6 92.32 High High
Pain 3 75.00 Quite High
Wound Healing 1 74.88 Quite High
Hyperalgesia 1 73.36 Quite High
Lactic Acidosis 1 64.56 Quite High
Acute Renal Failure 3 55.28 Quite High
Emergencies 2 43.76 Quite Low
Diabetes Mellitus 7 40.92 Quite Low
Increased Venous Pressure Under Development 1 40.52 Quite Low
Hypertension 2 39.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blood gas analysis was performed before the start of CPB, at 15 min of CPB, at 15 min of arrest, at the end of 30 min arrest, at the end of the total of 75 min of CPB, and at 1 hr post CPB, using an IL-GEM Premier 3000 blood gas analyzer (Global Medical Instrumentation, Ramsey, MI).
Negative_regulation (min) of CPB in blood
1) Confidence 0.36 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2553064 Disease Relevance 0.24 Pain Relevance 0
Pretreatment with captopril, a kininase II inhibitor, at 10 mg/kg i.p. or s.c., significantly increased the writhing response induced by a minimum effective dose (0.75 mg/kg i.p.) of phenylbenzoquinone (PBQ), by 91-148%. 1,10-Phenanthroline, a carboxypeptidase B inhibitor (2 mg/kg i.p.), in combination with captopril enhanced the algesic effect of PBQ by 309-360%.
Negative_regulation (inhibitor) of carboxypeptidase B
2) Confidence 0.30 Published 1991 Journal Agents Actions Section Abstract Doc Link 1793037 Disease Relevance 0.15 Pain Relevance 0.11
However, Demers and coworkers [5] found that a low hemoglobin level during CPB is associated with HL, and it is reasonable to interpret this information within the context of a low Do2 during CPB.
Negative_regulation (level) of CPB
3) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1794481 Disease Relevance 0.12 Pain Relevance 0
As a result of the covalent attachment of cysteine to polycarbophil, the inhibitory effect of the polymer towards carboxypeptidase A, carboxypeptidase B and chymotrypsin could be significantly improved.
Negative_regulation (effect) of carboxypeptidase B
4) Confidence 0.02 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0.03

General Comments

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