INT160914

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 4.69
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
neutrophil 4
microglia 3
astrocytes 1
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 88 100.00 Very High Very High Very High
cINOD 6 99.98 Very High Very High Very High
Dorsal horn 2 99.20 Very High Very High Very High
withdrawal 10 97.96 Very High Very High Very High
Morphine 20 97.52 Very High Very High Very High
Inflammation 102 95.88 Very High Very High Very High
fibrosis 30 93.68 High High
narcan 4 91.64 High High
Physical dependence 4 89.56 High High
Spinal cord 2 87.56 High High
Disease Link Frequency Relevance Heat
Disease 46 99.98 Very High Very High Very High
Atherosclerosis 24 99.82 Very High Very High Very High
Systemic Sclerosis 67 99.76 Very High Very High Very High
Obesity 128 98.52 Very High Very High Very High
Pathologic Constriction 8 98.08 Very High Very High Very High
Peptic Ulcer 6 97.04 Very High Very High Very High
INFLAMMATION 109 95.88 Very High Very High Very High
Eosinophilia 16 95.16 Very High Very High Very High
Fibrosis 29 93.68 High High
Diabetes Mellitus 15 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The occurrence of contralateral stenosis was associated with higher MMP-9 values, suggesting that a more severe atherosclerotic disease causes elevated MMP-9 levels.
Positive_regulation (causes) of Positive_regulation (elevated) of MMP-9 associated with pathologic constriction, atherosclerosis, metalloproteinase and disease
1) Confidence 0.57 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 1.16 Pain Relevance 0.56
The patients (n = 42) with SSc had higher concentrations of MMP-9 and of tissue inhibitor of metalloproteinase-1 (TIMP-1) and a higher ratio of MMP-9 to TIMP-1 in sera than healthy controls (n = 32).
Positive_regulation (concentrations) of Positive_regulation (ratio) of MMP-9 associated with metalloproteinase and systemic sclerosis
2) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 0.93 Pain Relevance 0.18
The increased MMP-9 activity is mainly distributed in the superficial dorsal horn and colocalized primarily with neurons and small numbers of astrocytes and microglia.
Positive_regulation (distributed) of Positive_regulation (increased) of MMP-9 in microglia associated with dorsal horn
3) Confidence 0.46 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.31 Pain Relevance 1.25
NSAIDs caused dose-dependent induction in MMP-9 and -3 activities and expressions in ulcerated gastric tissues along with significant infiltration of inflammatory cells and disruption of gastric mucosal layer.
Positive_regulation (caused) of Positive_regulation (induction) of MMP-9 associated with inflammation and cinod
4) Confidence 0.39 Published 2009 Journal J. Pineal Res. Section Abstract Doc Link 19522738 Disease Relevance 0.75 Pain Relevance 0.72
While HFD induced a highly significant increase of circulating MMP-9 in control animals, this increase was less profound in IR?
Positive_regulation (induced) of Positive_regulation (increase) of MMP-9 associated with metalloproteinase
5) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.42 Pain Relevance 0.57
The increased MMP-9 activity is mainly distributed in the superficial dorsal horn and colocalized primarily with neurons and small numbers of astrocytes and microglia.
Positive_regulation (distributed) of in astrocytes Positive_regulation (increased) of MMP-9 in microglia associated with dorsal horn
6) Confidence 0.16 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.31 Pain Relevance 1.25
Moreover, intranasal application of IL-17A resulted in pronounced neutrophil accumulation and increased levels of active matrix metallo protease 9 (MMP-9), another typical neutrophil-derived enzyme, in broncho-alveolar lavage (BAL) [80].
Positive_regulation (increased) of Positive_regulation (accumulation) of MMP-9 in neutrophil
7) Confidence 0.14 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.41 Pain Relevance 0
Moreover, intranasal application of IL-17A resulted in pronounced neutrophil accumulation and increased levels of active matrix metallo protease 9 (MMP-9), another typical neutrophil-derived enzyme, in broncho-alveolar lavage (BAL) [80].
Positive_regulation (increased) of Positive_regulation (levels) of MMP-9 in neutrophil
8) Confidence 0.14 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.41 Pain Relevance 0

General Comments

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