INT160915

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 10.25
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
macrophages 2
bone marrow 1
osteoclast 1
connective tissues 1
ears 1
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 265 100.00 Very High Very High Very High
agonist 58 97.12 Very High Very High Very High
cytokine 64 96.16 Very High Very High Very High
Cannabinoid 57 95.20 Very High Very High Very High
Inflammation 272 94.76 High High
fibrosis 28 93.68 High High
Arthritis 81 86.16 High High
cINOD 8 81.00 Quite High
complementary and alternative medicine 10 39.44 Quite Low
Acupuncture 1 22.72 Low Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 67 99.76 Very High Very High Very High
Cancer 481 99.52 Very High Very High Very High
Glaucoma 45 99.26 Very High Very High Very High
Hypercalcemia 19 98.96 Very High Very High Very High
Glioma 68 98.92 Very High Very High Very High
Peptic Ulcer 6 98.84 Very High Very High Very High
Hyperinsulinism 4 98.04 Very High Very High Very High
Alzheimer's Dementia 64 98.00 Very High Very High Very High
Disease 101 97.04 Very High Very High Very High
INFLAMMATION 270 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of shRNA constructs on MMP-9, uPAR, and cathepsin B
Regulation (Effect) of MMP-9
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.31 Pain Relevance 0
In this study, the efficacy of melatonin on activities of MMP-9 and -3 during prevention of gastric ulcers was tested.
Regulation (efficacy) of MMP-9 associated with peptic ulcer
2) Confidence 0.23 Published 2009 Journal J. Pineal Res. Section Abstract Doc Link 19522738 Disease Relevance 0.89 Pain Relevance 0.68
The patients (n = 42) with SSc had higher concentrations of MMP-9 and of tissue inhibitor of metalloproteinase-1 (TIMP-1) and a higher ratio of MMP-9 to TIMP-1 in sera than healthy controls (n = 32).
Regulation (concentrations) of MMP-9 associated with metalloproteinase and systemic sclerosis
3) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 0.91 Pain Relevance 0.18
S4B), indicating that they regulate MMP9 post-transcriptionally.


Regulation (regulate) of MMP9
4) Confidence 0.20 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.58 Pain Relevance 0.35
The combined treatment had a pronounced effect on MMP-9 detection, as compared to doxycycline treatment alone (29% and 40%, respectively, table 2).
Regulation (effect) of MMP-9
5) Confidence 0.19 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.78 Pain Relevance 0.04
In the combined treatment, MMP-9 immunoreactivity was reduced in 33% of the mice, in opposition to 71% of positive control animals, indicative of tissue improvement at the ECM level in most animals.
Regulation (immunoreactivity) of MMP-9
6) Confidence 0.19 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.17 Pain Relevance 0
Indeed, with increasing complexity of the model system, the importance of MMP-2 and MMP-9 became apparent.
Regulation (importance) of MMP-9 associated with metalloproteinase
7) Confidence 0.18 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.90 Pain Relevance 0.56
Taking that into account, our results underline the important role of insulin receptor-dependent regulation of MMP-9 in macrophages and further extend it to another hyperinsulinemia-related disease state i.e. the development of obesity-associated inflammation and insulin resistance.
Regulation (regulation) of MMP-9 in macrophages associated with inflammation, obesity, metalloproteinase, hyperinsulinism, insulin resistance and disease
8) Confidence 0.17 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.94 Pain Relevance 0.44
Antibodies targeting MMP-9, ?
Regulation (targeting) of MMP-9
9) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.23 Pain Relevance 0
PACG is associated with genes related to regulation of axial length and structural remodeling of connective tissues, such as membrane-type frizzled-related protein (MFRP) gene, matrix metalloproteinase 9 (MMP-9) gene, and methylenetetrahydrofolate reductase (MTHFR) gene [9-13].
Regulation (regulation) of MMP-9 in connective tissues associated with metalloproteinase and glaucoma
10) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 1.14 Pain Relevance 0.05
Decreased matrix metalloproteinase-9 delivery by CD11b-positive bone marrow-derived myelomonocytic cells was shown to be responsible for the angiogenic blockade observed in irradiated tumors [63].
Regulation (responsible) of matrix metalloproteinase-9 in bone marrow associated with cancer and metalloproteinase
11) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.72 Pain Relevance 0.05
Importantly, genes associated with bone destruction such as RANKL, MMP9, ATPV0D2, and TRAP are down-regulated in paws after MDL-1–Ig fusion treatment and up-regulated in anti–MDL-1 agonist treatment.
Regulation (regulated) of MMP9 associated with agonist
12) Confidence 0.12 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.39 Pain Relevance 0.29
SPEE significantly decreased nitrite content and induced nitric oxide synthase (iNOS) in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells, while it could not modulate cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 levels in the stimulated phages.
Neg (not) Regulation (modulate) of matrix metalloproteinase-9 in macrophage
13) Confidence 0.10 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19715750 Disease Relevance 0 Pain Relevance 0
The apparent regulation of the TRAP, RANKL, ATPV0D2, and MMP9 expression after anti–MDL-1 treatment suggests MDL-1 receptor activation may promote osteoclast development and function.
Regulation (regulation) of MMP9 in osteoclast
14) Confidence 0.07 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.34 Pain Relevance 0.21
Since we did not detect any significant changes in the levels of MMP-2 or MMP-9 activity between 66cl4beta3 and 66cl4pBabe cells by gelatin zymography, cooperation between ?
Neg (not) Regulation (changes) of MMP-9 associated with metalloproteinase
15) Confidence 0.07 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1557720 Disease Relevance 0.21 Pain Relevance 0.68
SB239063 on the other hand reduces neutrophil infiltration and the concentrations of IL-6 and MMP-9 in BALF of rats after endotoxin inhalation, suggesting its potential as an antiinflammatory agent in COPD (Underwood et al 2000).
Regulation (concentrations) of MMP-9 in neutrophil associated with pulmonary disease, inflammation and metalloproteinase
16) Confidence 0.04 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.05 Pain Relevance 0.40
Saline did not change the ear MMP-9 content compared to non-injected ears.
Neg (not) Regulation (change) of MMP-9 in ears
17) Confidence 0.03 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.70 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox