INT160928

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.90
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
sympathetic 1
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 2 97.58 Very High Very High Very High
Nerve growth factor 34 89.92 High High
Inflammation 18 65.60 Quite High
cytokine 46 50.00 Quite Low
Inflammatory response 6 40.52 Quite Low
Neurotransmitter 10 39.48 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 18 99.84 Very High Very High Very High
Urological Neuroanatomy 6 98.52 Very High Very High Very High
Brain Injury 68 92.04 High High
Injury 26 90.88 High High
Neuroblastoma 6 84.36 Quite High
Endometriosis 2 74.64 Quite High
Cancer 8 74.04 Quite High
INFLAMMATION 24 65.60 Quite High
Necrosis 4 39.84 Quite Low
Apoptosis 14 37.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Segregation of met-enkephalin from vesicular acetylcholine transporter and choline acetyltransferase in sympathetic preganglionic varicosities mostly lacking synaptophysin and synaptotagmin.
Negative_regulation (lacking) of synaptotagmin in sympathetic associated with enkephalin and increased venous pressure under development
1) Confidence 0.57 Published 2009 Journal Neuroscience Section Title Doc Link 19524025 Disease Relevance 0.85 Pain Relevance 0.17
The mechanism of the downregulation of MafK, SytI, and Syn-1 genes by Akt remains unclear.
Negative_regulation (downregulation) of SytI
2) Confidence 0.33 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.31 Pain Relevance 0.04
Effect of an Akt-specific inhibitor on expression of MafK, SytI, and Syn-1 genes in PC12 (WT-Akt) cells
Negative_regulation (inhibitor) of SytI
3) Confidence 0.33 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.05 Pain Relevance 0
B p65 was decreased significantly.
Negative_regulation (decreased) of p65
4) Confidence 0.09 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.36 Pain Relevance 0.03
B p65 was increased in all injured animals and decreased by progesterone treatment in comparison to vehicle-treated animals.
Negative_regulation (decreased) of p65
5) Confidence 0.09 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.32 Pain Relevance 0

General Comments

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