INT161

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 73
Speculated 64
Reported most in Abstract
Documents 615
Total Number 679
Disease Relevance 65.37
Pain Relevance 298.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
pituitary 70
hypothalamus 29
anterior pituitary 29
brain 28
dopamine neurons 22
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 1306 100.00 Very High Very High Very High
antagonist 974 100.00 Very High Very High Very High
Dopamine 779 100.00 Very High Very High Very High
Morphine 754 100.00 Very High Very High Very High
agonist 743 100.00 Very High Very High Very High
Opioid 638 100.00 Very High Very High Very High
opiate 475 100.00 Very High Very High Very High
Serotonin 311 100.00 Very High Very High Very High
tetrodotoxin 262 100.00 Very High Very High Very High
Enkephalin 229 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 806 100.00 Very High Very High Very High
Depression 122 100.00 Very High Very High Very High
Galactorrhea 104 100.00 Very High Very High Very High
Urological Neuroanatomy 95 100.00 Very High Very High Very High
Reprotox - General 1 44 100.00 Very High Very High Very High
Pain 32 100.00 Very High Very High Very High
Injury 24 100.00 Very High Very High Very High
Morphine Dependence 18 100.00 Very High Very High Very High
Acromegaly 17 100.00 Very High Very High Very High
Hypoglycemia 7 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of morphine on the serum prolactin levels of morphine-tolerant and nontolerant male rats and of the in vitro release of pituitary prolactin.
Regulation (Effects) of Localization (release) of prolactin in pituitary associated with narcan and morphine
1) Confidence 0.62 Published 1978 Journal Jpn. J. Pharmacol. Section Title Doc Link 745306 Disease Relevance 0 Pain Relevance 1.27
The effect of dermorphin, a new opioid peptide originally isolated from amphibian skin, on the release of prolactin (Prl) was studied in vivo and in vitro.
Regulation (effect) of Localization (release) of prolactin in skin associated with opioid
2) Confidence 0.62 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6504268 Disease Relevance 0.09 Pain Relevance 0.25
The peripubertal period in the female rat is the time when the stimulatory effects of opioids on prolactin (PRL) secretion develop.
Regulation (effects) of Localization (secretion) of PRL associated with opioid
3) Confidence 0.62 Published 2003 Journal Dev Psychobiol Section Abstract Doc Link 15027420 Disease Relevance 0 Pain Relevance 0.50
The suppressive effect of morphine on PRL secretion was not observed in rats treated with the opiate antagonist naloxone (2.5 mg/kg).
Regulation (effect) of Localization (secretion) of PRL associated with antagonist, narcan, opiate and morphine
4) Confidence 0.62 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3950867 Disease Relevance 0.16 Pain Relevance 1.46
The suppressive effect of morphine on PRL secretion was observed 3 to 6 hr after its administration and at doses of 10 to 20 mg/kg.
Regulation (effect) of Localization (secretion) of PRL associated with morphine
5) Confidence 0.62 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3950867 Disease Relevance 0.19 Pain Relevance 1.11
From these results, the following conclusions were drawn: 1) the PRL surge on the afternoon of proestrus occurs without synthesis of the hormone in the pituitary; 2) PRL secretion on the afternoon of estrus is accompanied by its synthesis in the gland; 3) the PRL response is distinct for each type of stress applied; and 4) PRL secretion is thus regulated by different mechanisms in proestrus and estrus.
Regulation (regulated) of Localization (secretion) of PRL in gland associated with stress
6) Confidence 0.62 Published 1989 Journal Jikken Dobutsu Section Abstract Doc Link 2806389 Disease Relevance 0.17 Pain Relevance 0.23
Apparently hypothalamic regulation of PRL secretion was disrupted in these three patients after bromocriptine therapy.
Regulation (regulation) of Localization (secretion) of PRL
7) Confidence 0.62 Published 1983 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6405619 Disease Relevance 0.73 Pain Relevance 0.15
This raises a question regarding the importance of input from the posterior pituitary to the control of PRL secretion during the estrous cycle.
Regulation (control) of Localization (secretion) of PRL in posterior pituitary
8) Confidence 0.62 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3748304 Disease Relevance 0 Pain Relevance 0.08
However, the probable existence of other PRL-inhibiting factors as well as PRL-releasing factors opens to question the role of dopamine in the dynamic regulation of PRL secretion.
Regulation (regulation) of Localization (secretion) of PRL associated with dopamine
9) Confidence 0.62 Published 1979 Journal Endocrinology Section Abstract Doc Link 487998 Disease Relevance 0 Pain Relevance 0.30
Noradrenergic mechanisms have a stimulatory role in regulating prolactin (PRL) secretion in the rat.
Regulation (regulating) of Localization (secretion) of prolactin
10) Confidence 0.62 Published 1989 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2813439 Disease Relevance 0 Pain Relevance 0.19
The effect of melatonin on the prolactin (PRL) release induced by treatment with naloxone, naloxone methyliodide, naltrexone and nalmefene were studied in adult male rats.
Regulation (effect) of Localization (release) of prolactin associated with narcan
11) Confidence 0.62 Published 1995 Journal Endocr. Res. Section Abstract Doc Link 7588425 Disease Relevance 0 Pain Relevance 0.37
Serotoninergic control of prolactin secretion in prepubertal male rats.
Regulation (control) of Localization (secretion) of prolactin
12) Confidence 0.62 Published 1994 Journal Eur. J. Endocrinol. Section Title Doc Link 7524955 Disease Relevance 0 Pain Relevance 0.23
Effect of naltrexone on stress-induced bioactive prolactin release in aging male rats.
Regulation (Effect) of Localization (release) of prolactin associated with stress and aging
13) Confidence 0.62 Published 1991 Journal Neurobiol. Aging Section Title Doc Link 1646967 Disease Relevance 0.52 Pain Relevance 0.21
Effects of the opiate receptor antagonist naltrexone (NALT, 10 mg/kg) on basal and novel environment stress-induced prolactin (PRL) release were examined in young (3-5 month) and old (22-24 month) male Copenhagen-Fischer 344 rats.
Regulation (Effects) of Spec (examined) Localization (release) of PRL associated with stress, antagonist and opiate
14) Confidence 0.62 Published 1991 Journal Neurobiol. Aging Section Abstract Doc Link 1646967 Disease Relevance 0.40 Pain Relevance 0.15
The role of the serotoninergic system in the control of prolactin (PRL) secretion has been studied in prepubertal male rats.
Regulation (role) of Localization (secretion) of prolactin
15) Confidence 0.62 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7524955 Disease Relevance 0 Pain Relevance 0.15
On the other hand, whereas animals pretreated with ketanserin or LY53857 (both at a dose of 5 mg/kg BW, ip), two specific 5-HT2 receptor antagonists, had no effect on fentanyl-induced PRL secretion, the same treatment significantly blocked 5-HT-induced PRL secretion.
Neg (no) Regulation (effect) of Localization (secretion) of PRL associated with antagonist
16) Confidence 0.62 Published 1989 Journal Endocrinology Section Abstract Doc Link 2551630 Disease Relevance 0 Pain Relevance 0.57
These studies examined the hypothalamic site and receptor subtype mediating the serotonergic (5-HT) control of PRL secretion in conscious male rats.
Regulation (control) of Localization (secretion) of PRL
17) Confidence 0.62 Published 1993 Journal Endocrinology Section Abstract Doc Link 8344205 Disease Relevance 0 Pain Relevance 0.17
RU 24969 injected icv significantly stimulated PRL secretion (11-fold) at doses 500-fold lower than the peripherally effective doses (10 micrograms/kg vs. 5 mg/kg), suggesting a role for central 5-HT receptors in the regulation of PRL secretion.
Regulation (role) of Localization (secretion) of PRL
18) Confidence 0.62 Published 1993 Journal Endocrinology Section Abstract Doc Link 8344205 Disease Relevance 0 Pain Relevance 0.11
Pretreatment with fluoxetine (10 mg/kg i.p.) 16 hr before MDMA administration significantly blunted the effect of MDMA on corticosterone but not PRL secretion.
Regulation (effect) of Localization (secretion) of PRL associated with fluoxetine
19) Confidence 0.62 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2898523 Disease Relevance 0.08 Pain Relevance 0.27
Neuroendocrine control of prolactin secretion: the role of the serotonergic system.
Regulation (control) of Localization (secretion) of prolactin
20) Confidence 0.62 Published 1991 Journal Chin J Physiol Section Title Doc Link 1874034 Disease Relevance 0.10 Pain Relevance 0.07

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