INT161011

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (St13) Golgi apparatus (Cpe) protein complex (St13)
cytoplasm (St13) cytosol (St13) protein folding (St13)
Anatomy Link Frequency
caudate-putamen 1
Cpe (Mus musculus)
St13 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 11 100.00 Very High Very High Very High
Dopamine 5 100.00 Very High Very High Very High
Substantia nigra 1 97.88 Very High Very High Very High
agonist 58 91.36 High High
opioid receptor 7 87.44 High High
analgesia 2 62.04 Quite High
Opioid 4 61.64 Quite High
Pain 14 46.32 Quite Low
IPN 8 37.28 Quite Low
Lasting pain 1 17.88 Low Low
Disease Link Frequency Relevance Heat
Loss Of Sense Of Smell 1 93.04 High High
Parkinson's Disease 2 86.08 High High
Disease 6 85.84 High High
Neuroblastoma 3 80.64 Quite High
Pain 15 46.32 Quite Low
Gliosis 1 41.04 Quite Low
Inflammatory Pain 8 37.28 Quite Low
Stress 1 8.04 Low Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We evaluated behavioral deficits (olfactory and motor impairment), neurodegeneration (loss of tyrosine hydroxylase (TH)-positive cells in the substantia nigra pars compacta, SNc), biochemical markers of functional impairment in the caudate-putamen (CPu) (striatal enkephalin mRNA, DA and DOPAC levels), and glial reactivity (CD11b and GFAP immunoreactivity in the SNc and CPu) at progressive time-points (after 1, 3, 7, and 10 administrations of MPTPp).
enkephalin mRNA Binding (immunoreactivity) of SNc in caudate-putamen associated with dopamine, substantia nigra and enkephalin
1) Confidence 0.03 Published 2009 Journal Neurotox Res Section Abstract Doc Link 19526289 Disease Relevance 0.53 Pain Relevance 0.37
The two synthetic alkaloids, SNC80 and ARM390, had affinities which were approximately 10 times greater than the affinity of Met-enkephalin.
Met-enkephalin Binding (affinity) of SNC80 associated with enkephalin
2) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.08 Pain Relevance 0.70

General Comments

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