INT161027

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.34
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (RPE) cytosol (RPE) small molecule metabolic process (RPE)
carbohydrate metabolic process (RPE)
Anatomy Link Frequency
outflow 2
photoreceptor 2
lung 1
RPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 91.32 High High
potassium channel 28 85.28 High High
anesthesia 3 64.36 Quite High
adenocard 11 53.28 Quite High
cytokine 12 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 14 100.00 Very High Very High Very High
Frailty 8 100.00 Very High Very High Very High
Age-related Macular Degeneration 72 99.94 Very High Very High Very High
Myopia 46 99.34 Very High Very High Very High
Hypertrophy 2 98.88 Very High Very High Very High
Disease 76 98.14 Very High Very High Very High
Ocular Hypertension 4 93.08 High High
INFLAMMATION 4 91.32 High High
Retina Disease 21 90.96 High High
Renal Insufficiency 1 82.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methods to prevent RPE and management of one-lung ventilation are described.
Negative_regulation (prevent) of RPE in lung associated with heart rate under development
1) Confidence 0.37 Published 2009 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 19527970 Disease Relevance 1.54 Pain Relevance 0.11
A bumetanide induced reduction in RPE outflow is also a likely cause of the increase in VC depth observed in the bumetanide injected eyes reared with 0D and+10D lenses, given that aqueous humour production and intraocular pressure changes under bumetanide are minimal (at least in mouse and monkey [36], [37]).
Negative_regulation (reduction) of RPE in outflow associated with ocular hypertension
2) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481396 Disease Relevance 0.15 Pain Relevance 0
The only significant finding was a decreased RPE for the caffeinated coffee as compared to the decaffeinated treatment [70].
Negative_regulation (decreased) of RPE
3) Confidence 0.15 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2824625 Disease Relevance 0 Pain Relevance 0
Thus, in a second experiment, we tested the idea that if negative lens defocus results in myopia and ocular elongation through a reduction in the outflow of fluid across the RPE, then intravitreal injection of the diuretic bumetanide would restore RPE fluid flow as evidenced by relative suppression of abnormal vitreal chamber growth and inhibition of myopia.


Negative_regulation (reduction) of RPE in outflow associated with myopia
4) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481396 Disease Relevance 0.28 Pain Relevance 0.25
STGD is clinically characterized by RPE and photoreceptor inner segment lipofuscin accumulation, RPE and choroidal vascular atrophy, macular photoreceptor loss, and reactive Müller glial hypertrophy [37,38] with progressive loss of central visual acuity during the first two decades [21].
Negative_regulation (loss) of RPE in photoreceptor associated with hypertrophy, frailty and disease
5) Confidence 0.10 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.10 Pain Relevance 0.03
Further, inhibition of lysosomal enzymes in the RPE leads to attenuation of exocytosis and release of incompletely degraded phagolysosomes into the basal and intercellular spaces between adjacent cells [17], [20], [46].
Negative_regulation (inhibition) of RPE
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.64 Pain Relevance 0
Bergmann and coworkers demonstrated that A2E, which accumulates in age-related macular degeneration (AMD), impaired the proton pump of the lysosomal membrane in cultured RPE, altered the function of the lysosome and thereby slowed the processing of photoreceptor outer segments [36].
Negative_regulation (impaired) of RPE in photoreceptor associated with age-related macular degeneration
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.63 Pain Relevance 0

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