INT16104

Context Info Confidence 0.03 First Reported 1991 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.53 Pain Relevance 0.14

signal transduction (GNRH1) extracellular space (GNRH1) extracellular region (GNRH1) cell-cell signaling (GNRH1)

GNRH1 (Homo sapiens) Lhb (Mus musculus)

Pain Link Frequency Relevance Heat agonist 3 91.16 Pain 2 62.32 palliative 1 25.00

Disease Link Frequency Relevance Heat Obesity 2 95.44 Precocious Puberty 2 79.92 Hamartoma 3 78.16 Pain 2 62.32 Prostate Cancer 3 62.00 Reprotox - General 1 1 25.00 Hyperplasia 1 25.00 Toxicity 1 25.00 Increased Venous Pressure Under Development 1 25.00 Benign Prostatic Hypertrophy 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that the patients' mean +/- SD peak GnRH-stimulated LH and FSH had returned to the normal range by 1 yr after stopping therapy.

GnRH Positive_regulation (stimulated) of LH

1) Confidence 0.03 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11095429 Disease Relevance 0.47 Pain Relevance 0.14

Leuprorelin (leuprolide acetate) is a synthetic analogue of gonadotrophin-releasing hormone (GnRH) [luteinising hormone-releasing hormone (LHRH)] which initially stimulates luteinising hormone (LH) and hence testicular androgen release; continuous administration then results in profound suppression of these hormones.

gonadotrophin-releasing hormone Positive_regulation (stimulates) of LH

2) Confidence 0.00 Published 1991 Journal Drugs Aging Section Abstract Doc Link 1794035 Disease Relevance 0.06 Pain Relevance 0

General Comments

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