INT161048

Context Info Confidence 0.56 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.47 Pain Relevance 0.86

nucleus (Nrm, Prdm4) cytosol (Prdm4) nucleoplasm (Prdm4) nuclear envelope (Nrm) intracellular (Prdm4) DNA binding (Prdm4)

Nrm (Rattus norvegicus) Prdm4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Raphe magnus 8 100.00 allodynia 5 99.96 Dermatone 1 97.96 Spinal cord 3 75.00 Raphe 1 75.00 medulla 1 56.20 Serotonin 1 47.44 Pain 2 25.00

Disease Link Frequency Relevance Heat Frailty 5 100.00 Neuropathic Pain 5 99.96 Injury 6 98.64 Nociception 2 96.64 Contusions 2 89.20 Gliosis 1 80.48 Skin Allergy 1 60.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Altered NRM activity is unlikely to cause SCI allodynia, since inhibited and excited classes are believed to oppositely modulate nociception.

NRM Positive_regulation (cause) of SCI associated with nociception, raphe magnus, allodynia and frailty

1) Confidence 0.56 Published 2009 Journal J Rehabil Res Dev Section Abstract Doc Link 19533524 Disease Relevance 1.47 Pain Relevance 0.86

General Comments

This test has worked.