INT161079

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.82
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
sensory neurons 1
neurons 1
Mcs18 (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 14 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
Pain 6 99.80 Very High Very High Very High
dorsal root ganglion 6 99.24 Very High Very High Very High
Analgesic 2 98.04 Very High Very High Very High
Inflammation 2 77.92 Quite High
Hyperalgesia 2 76.72 Quite High
ASIC 2 66.32 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 98.76 Very High Very High Very High
INFLAMMATION 2 77.92 Quite High
Hyperalgesia 2 76.72 Quite High
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report that the pure natural product MCS-18 isolated from this source is a potent, specific and reversible antagonist of the capsaicin receptor, TRPV1, expressed in rat dorsal root ganglion (DRG) neurons.
MCS-18 Negative_regulation (antagonist) of TRPV1 in neurons associated with ganglion cysts, dorsal root ganglion, qutenza and antagonist
1) Confidence 0.40 Published 2010 Journal Physiol Res Section Abstract Doc Link 19537933 Disease Relevance 0.42 Pain Relevance 0.70
Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist of the capsaicin receptor, TRPV1, in rat cultured sensory neurons.
MCS-18 Negative_regulation (antagonist) of TRPV1 in sensory neurons associated with qutenza and antagonist
2) Confidence 0.35 Published 2010 Journal Physiol Res Section Title Doc Link 19537933 Disease Relevance 0.40 Pain Relevance 1.20

General Comments

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