INT161082

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Context Info
Confidence 0.23
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
tail 1
asp3 (Mus musculus)
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 1 99.54 Very High Very High Very High
Antinociceptive 4 90.24 High High
Glutamate 1 88.04 High High
bradykinin 1 87.60 High High
qutenza 2 85.68 High High
Hyperalgesia 1 68.96 Quite High
narcan 1 47.92 Quite Low
Inflammation 3 25.00 Low Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Toxicity 2 98.92 Very High Very High Very High
Nociception 3 92.96 High High
Hyperalgesia 4 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute toxicity of 3-ASP (1-50 mg/kg, per oral) was investigated in mice. 3-ASP neither caused toxicity nor affects locomotor activity in the rota-rod test. 3-ASP did not change plasma aspartate (AST) and alanine aminotransferase (ALT) activities, urea and creatinine levels. 3-ASP caused a significant increase in tail-immersion and hot-plate response latencies time. 3-ASP inhibited early and late phases of nociception caused by intraplantar (i.pl.) injection of formalin. 3-ASP reduced nociception produced by i.pl. injection of glutamate, bradykinin, phorbol myristate acetate (PMA) and capsaicin in mice.
3-ASP Neg (not) Regulation (change) of ALT in tail associated with nociception, toxicity, glutamate, qutenza, eae and bradykinin
1) Confidence 0.23 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19538987 Disease Relevance 0.67 Pain Relevance 0.40

General Comments

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