INT161085

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.36
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch3) plasma membrane (Notch3) nucleus (Notch3)
Anatomy Link Frequency
astrocyte 1
smooth muscle cells 1
parenchyma 1
Notch3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 1 95.28 Very High Very High Very High
Central nervous system 2 91.04 High High
Migraine 2 89.48 High High
interneuron 1 45.24 Quite Low
medulla 1 43.92 Quite Low
Hippocampus 6 41.08 Quite Low
Pyramidal cell 1 40.32 Quite Low
Inflammation 47 5.00 Very Low Very Low Very Low
cINOD 37 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cadasil 21 99.52 Very High Very High Very High
Targeted Disruption 25 96.78 Very High Very High Very High
Dementia 15 95.36 Very High Very High Very High
Cognitive Disorder 16 94.12 High High
Nervous System Malformation 1 91.52 High High
Stroke 57 90.96 High High
Epilepsy 1 90.20 High High
Headache 1 89.48 High High
Disease 97 88.04 High High
Neurodegenerative Disease 5 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Linked to mutations in the NOTCH3 gene, CADASIL vasculopathy is associated with accumulation of granular osmiophilic material and NOTCH3 extracellular domain around small caliber arteries and arterioles, and eventual loss of vascular smooth muscle cells.
Positive_regulation (accumulation) of NOTCH3 in smooth muscle cells associated with cadasil
1) Confidence 0.41 Published 2010 Journal Stroke Section Abstract Doc Link 20876488 Disease Relevance 1.20 Pain Relevance 0.09
Pathogenetic mutations alter the number of cysteine residues in the extracellular domain of NOTCH3, which accumulates in small arteries of affected individuals.
Positive_regulation (accumulates) of NOTCH3
2) Confidence 0.41 Published 2009 Journal Lancet Neurol Section Abstract Doc Link 19539236 Disease Relevance 1.17 Pain Relevance 0.13
Activation of Notch-1 and Notch-3 in embryonic progenitors promotes radial glial fate and astrocyte fate postnatally (Gaiano et al., 2000).
Positive_regulation (Activation) of Notch-3 in astrocyte
3) Confidence 0.21 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.36 Pain Relevance 0.05
Although transgenic mice showed no evidence of prominent brain parenchyma damage, both cerebral and peripheral arteries were demonstrated to contain granular material deposits and Notch3 accumulation typical of CADASIL.
Positive_regulation (accumulation) of Notch3 in parenchyma associated with targeted disruption and cadasil
4) Confidence 0.18 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 1.62 Pain Relevance 0

General Comments

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