INT161097

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2009
Negated 5
Speculated 0
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 7.76
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Epc1) nucleus (Epc1)
Anatomy Link Frequency
bone marrow 3
left lung 3
muscle 2
blood 2
endothelial cell 2
Epc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 28 99.56 Very High Very High Very High
Inflammation 201 95.56 Very High Very High Very High
Thoracotomy 66 95.08 Very High Very High Very High
imagery 32 94.12 High High
ischemia 275 93.44 High High
cytokine 46 86.48 High High
anesthesia 99 81.68 Quite High
halothane 110 80.16 Quite High
aspirin 10 76.48 Quite High
agonist 2 75.08 Quite High
Disease Link Frequency Relevance Heat
Adhesions 14 100.00 Very High Very High Very High
Cancer 118 99.84 Very High Very High Very High
Cv General 3 Under Development 24 99.56 Very High Very High Very High
Hypoxia 121 98.28 Very High Very High Very High
Bronchogenic Carcinoma 22 98.24 Very High Very High Very High
Adult Respiratory Distress Syndrome 550 97.68 Very High Very High Very High
Wound Healing 66 96.76 Very High Very High Very High
Hypertension 66 96.60 Very High Very High Very High
Diabetes Mellitus 12 96.32 Very High Very High Very High
Cv Unclassified Under Development 277 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, expression of endothelial surface markers (Figure 2G) on EPC and hL-MVEC were compared by flow cytometry.
Gene_expression (expression) of EPC
1) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0 Pain Relevance 0
Already one day after transplantation, SP-DiIC18(3) – labeled EPC were detectable in the injured lung tissue.
Gene_expression (detectable) of EPC in lung
2) Confidence 0.39 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.44 Pain Relevance 0.09
Intravenous injection of EPC
Gene_expression (injection) of EPC
3) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.06 Pain Relevance 0.37
Vasculogenic properties of rat bone marrow-derived EPC
Gene_expression (derived) of EPC in bone marrow
4) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0 Pain Relevance 0
EPC were checked for the presence of CD146-PE (P1H12) (Chemicon, Temecula, USA), CD133-PE (Milteny-Biotec, Bergisch-Gladbach, Germany), VEGF receptor-2 (KDR; R&D, Wiesbaden, Germany) and CD106 (clone 1.G11B1, Serotec, Oxford, UK).
Gene_expression (checked) of EPC
5) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0 Pain Relevance 0
After a washing procedure in buffer solution EPC were stained with the anionic sulfophenyl cell tracer SP-DiIC18(3) (Molecular Probes, Leyden, The Netherlands), a formaldehyde and acetone resistant Dil dye at a concentration of 2 ?
Gene_expression (stained) of EPC
6) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.12 Pain Relevance 0
Ex vivo cell tracer labeling of EPC
Gene_expression (labeling) of EPC
7) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.13 Pain Relevance 0
These findings, together with that of high amounts of circulating EC found after injection of EPC in venous blood, also corroborated that EPC found in the transplanted lung are not explained by simple embolism and suggests that a tropism of such cells to vasculogenic or wound healing areas might occur.
Neg (not) Gene_expression (explained) of EPC in blood associated with wound healing and cva
8) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.66 Pain Relevance 0.08
These findings, together with that of high amounts of circulating EC found after injection of EPC in venous blood, also corroborated that EPC found in the transplanted lung are not explained by simple embolism and suggests that a tropism of such cells to vasculogenic or wound healing areas might occur.
Gene_expression (injection) of EPC in blood associated with wound healing and cva
9) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.62 Pain Relevance 0.08
Flow cytometry analyses of circulating EC after peripheral EPC transplantation
Gene_expression (transplantation) of EPC
10) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.05 Pain Relevance 0
In vivo experimental protocol including the intravenous injection of EPC
Gene_expression (injection) of EPC
11) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.07 Pain Relevance 0.15
Furthermore, we were able to detect CD133-positive EPC in tumor tissue of patients suffering from bronchial carcinoma [92], a concept that has been questioned experimentally [93].
Gene_expression (detect) of EPC associated with bronchogenic carcinoma and cancer
12) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 1.40 Pain Relevance 0.16
l of Matrigel (Becton Dickinson, Heidelberg, Germany) was subcutanously administered into the left-sided flank subcutis of lung transplant recipients with EPC injection eight days before transplantation in order to assess angiogenesis as shown in figure five.


Gene_expression (injection) of EPC in lung
13) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.14 Pain Relevance 0
Furthermore, EPC (Figure 2E) as well as rAEC (Figure 2F) uniformly expressed vWF in their cytoplasmic granules.
Gene_expression (expressed) of EPC
14) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0 Pain Relevance 0
Still 9 days after injection of SP-DiIC18(3)-labeled cells, EPC were detectable in the transplanted left lung and seemingly integrated in capillary-like structures therein but not in the non-transplanted right lung.
Gene_expression (detectable) of EPC in capillary
15) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.22 Pain Relevance 0.05
Specific immunofluorecence for SP-DiIC18(3), was found throughout the left lung in all left lung transplanted animals (n = 9) while in the right lung or other organs of the same rats transplanted EPC were virtually not found.
Neg (not) Gene_expression (found) of EPC in left lung
16) Confidence 0.34 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.39 Pain Relevance 0.08
EPC were not detectable in the investigated specimens of other tissues such as myocardium, kidney and liver by fluorescence microscopy so far.
Neg (not) Gene_expression (detectable) of EPC in liver
17) Confidence 0.30 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.10 Pain Relevance 0.03
As depicted, EPC and hL-MVEC express the markers CD146 (P1H12), CD133, KDR and CD106.
Gene_expression (express) of EPC
18) Confidence 0.30 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0 Pain Relevance 0
EPC were detected at a percentage between 3 to 11% in the left lung in our model.
Gene_expression (detected) of EPC in left lung
19) Confidence 0.30 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.19 Pain Relevance 0.05
However, the number of EPC detected in the injured left lung and in the administered Matrigel might be underestimated as after cell division the fluorescent cell marker has been shown to loose its intensity.
Gene_expression (detected) of EPC in left lung
20) Confidence 0.30 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.34 Pain Relevance 0.07

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