INT161105

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Context Info
Confidence 0.78
First Reported 2009
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 20
Total Number 26
Disease Relevance 17.84
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ephx2) Golgi apparatus (Ephx2) nucleolus (Ephx2)
peroxisome (Ephx2) cytoplasm (Ephx2)
Anatomy Link Frequency
brain 3
kidney 2
blood 1
liver 1
AT-1 1
Ephx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 542 99.96 Very High Very High Very High
amygdala 4 99.50 Very High Very High Very High
fibrosis 36 98.94 Very High Very High Very High
cva 54 97.68 Very High Very High Very High
Bile 6 96.04 Very High Very High Very High
Pain 36 95.08 Very High Very High Very High
antagonist 36 95.04 Very High Very High Very High
IPN 18 93.32 High High
ischemia 8 92.40 High High
Analgesic 20 89.56 High High
Disease Link Frequency Relevance Heat
Atherosclerosis 954 99.96 Very High Very High Very High
INFLAMMATION 560 99.96 Very High Very High Very High
Hypertension 366 99.74 Very High Very High Very High
Disorder Of Lipid Metabolism 216 99.12 Very High Very High Very High
Fibrosis 60 98.94 Very High Very High Very High
Renal Failure 54 98.80 Very High Very High Very High
Atherosclerotic Plaque 54 98.20 Very High Very High Very High
Cv General 3 Under Development 54 97.68 Very High Very High Very High
Sprains And Strains 102 97.16 Very High Very High Very High
Pain 36 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In sEH-deficient mice and sEH-expressing mammalian cell lines, low cholesterol levels have been found.
Gene_expression (expressing) of sEH
1) Confidence 0.78 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.90 Pain Relevance 0
Increased sEH gene expression and activity along with renal eicosanoid metabolism have been reported to participate in the pathogenesis of hypertension in SHRs [14].
Gene_expression (expression) of sEH gene associated with hypertension
2) Confidence 0.78 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.83 Pain Relevance 0.07
sEH is expressed in many organisms, including plants, nematodes, and humans.
Gene_expression (expressed) of sEH
3) Confidence 0.78 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.91 Pain Relevance 0.08
Investigating the role of sEH in hypertensive animals, Fornage et al. [26] reported that sub-strains of SHR and its wild-type control WKY rats obtained from different sources (eg, Heidelberg vs Charles River) show differences in the level of Ephx2 (sEH) gene expression, activity, and protein abundance.
Gene_expression (expression) of sEH associated with hypertension and sprains and strains
4) Confidence 0.78 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.65 Pain Relevance 0.03
Investigating the role of sEH in hypertensive animals, Fornage et al. [26] reported that sub-strains of SHR and its wild-type control WKY rats obtained from different sources (eg, Heidelberg vs Charles River) show differences in the level of Ephx2 (sEH) gene expression, activity, and protein abundance.
Gene_expression (expression) of Ephx2 associated with hypertension and sprains and strains
5) Confidence 0.78 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.65 Pain Relevance 0.03
This study revealed that Ang II dose-dependently upregulated cardiac sEH expression involving AP-1 transcription factor activation, which could be reversed by losartan, an angiotensin type 1 (AT-1) receptor antagonist.
Gene_expression (expression) of sEH in AT-1 associated with antagonist
6) Confidence 0.78 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.78 Pain Relevance 0.12
Furthermore, sEH is widely expressed in the liver, kidney, heart, brain, and other tissues; thus the anti-inflammatory effects of sEHI offer novel treatment options in a range of disease models, including atherosclerosis, pain, stroke, and diabetes [3••, 4••, 17–20].
Gene_expression (expressed) of sEH in kidney associated with pain, inflammation, diabetes mellitus, stroke, atherosclerosis and disease
7) Confidence 0.78 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 1.38 Pain Relevance 0.41
The positive findings in the F2 progeny were also supported by the semi-quantitative Western blot analyses showing high Ephx2 gene expression in the renal cortex of the parental WKY (Heidelberg) but not in SHR (Heidelberg).
Gene_expression (expression) of Ephx2 in renal cortex
8) Confidence 0.78 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.32 Pain Relevance 0
Here, we analyzed the expression pattern of sEH and of another important member of the EH family, microsomal epoxide hydrolase (mEH), in mouse brain by immunohistochemistry.
Spec (analyzed) Gene_expression (expression) of sEH in brain
9) Confidence 0.76 Published 2009 Journal Neuroscience Section Abstract Doc Link 19540314 Disease Relevance 0.18 Pain Relevance 0.21
Interestingly, also in the lung we previously observed that fibrosis occurring during pulmonary hypertension reduced the sEH expression [9] suggesting that this effect is more important than the previously reported induction of sEH by angiotensin II [46].
Gene_expression (expression) of sEH in lung associated with fibrosis and hypertension
10) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.57 Pain Relevance 0.08
In this study we observed that the sEH expression decreases during progressive renal failure.
Gene_expression (expression) of sEH associated with renal failure
11) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.58 Pain Relevance 0.08
Interestingly, 5/6-Nx also resulted in a marked decrease in the renal expression of the sEH on the protein, as well as on the mRNA level (Fig. 6B).
Gene_expression (expression) of sEH
12) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.18 Pain Relevance 0.07
In order to determine whether changes in EET production underlie the effects observed, the renal expression of sPLA2, sEH and CYP450 enzymes was determined.
Spec (determined) Gene_expression (expression) of sEH
13) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.15 Pain Relevance 0.05
A strong correlation was found between the inheritance of these alleles and the gene expression, protein abundance (confirmed by semi-quantitative Western blot analysis), and sEH activity (in renal cortex) but not blood pressure in the F2 progeny obtained from crossing the SHR and WKY Heidelberg strains.
Gene_expression (expression) of sEH in blood associated with sprains and strains
14) Confidence 0.67 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.49 Pain Relevance 0
Inhibitors of sEH stabilize EETs, and prolong the duration of action of EETs, thus, enhancing the effects of reducing hypertension, inflammation, and pain
Gene_expression (stabilize) of sEH associated with pain, inflammation and hypertension
15) Confidence 0.67 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.44 Pain Relevance 0.22
Fig. 2Representative structures of soluble epoxide hydrolase (sEH) inhibitors.
Gene_expression (structures) of sEH
16) Confidence 0.67 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.40 Pain Relevance 0.13
Fig. 2Representative structures of soluble epoxide hydrolase (sEH) inhibitors.
Gene_expression (structures) of soluble epoxide hydrolase
17) Confidence 0.67 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.40 Pain Relevance 0.13
An sEH inhibitor, AR9276, was administrated in drinking water (1.5 g/L) for 4 weeks in apolipoprotein E–deficient mice (6-months of age) chronically infused with angiotensin II (1.44 mg/kg per day) to accelerate atherosclerosis development and induce abdominal aneurysm formation
Gene_expression (inhibitor) of sEH associated with atherosclerosis, aneurism and disorder of lipid metabolism
18) Confidence 0.67 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.97 Pain Relevance 0.09
We find sEH immunoreactivity almost exclusively in astrocytes throughout the brain, except in the central amygdala, where neurons are also positive for sEH. mEH immunoreactivity is abundant in brain vascular cells (endothelial and smooth muscle cells) and in choroid plexus epithelial cells.
Gene_expression (positive) of sEH in brain associated with amygdala
19) Confidence 0.66 Published 2009 Journal Neuroscience Section Abstract Doc Link 19540314 Disease Relevance 0.14 Pain Relevance 0.31
Inhibitors of sEH reduce inflammation and prevent the development of atherosclerotic plaques, presumably via an increase in EETs and other epoxy lipids, as well as a decrease in the corresponding diols [3••, 4••].
Gene_expression (reduce) of sEH in plaques associated with atherosclerotic plaque and inflammation
20) Confidence 0.59 Published 2010 Journal Curr Atheroscler Rep Section Body Doc Link PMC2857794 Disease Relevance 0.73 Pain Relevance 0.15

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