INT161107

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 58
Total Number 59
Disease Relevance 49.92
Pain Relevance 7.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn2) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)
cytoplasm (Ptpn2)
Anatomy Link Frequency
neurons 7
brains 4
dopaminergic neurons 3
tail 2
microglia 2
Ptpn2 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 155 99.92 Very High Very High Very High
Eae 103 99.64 Very High Very High Very High
anesthesia 35 99.58 Very High Very High Very High
Dopamine 490 99.24 Very High Very High Very High
COX-2 inhibitor 185 99.22 Very High Very High Very High
deep brain stimulation 114 98.90 Very High Very High Very High
Inflammation 491 98.88 Very High Very High Very High
Spinal cord 50 98.40 Very High Very High Very High
Substantia nigra 436 98.20 Very High Very High Very High
imagery 38 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 4248 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 243 100.00 Very High Very High Very High
Toxicity 202 100.00 Very High Very High Very High
Injury 195 100.00 Very High Very High Very High
Reperfusion Injury 270 99.96 Very High Very High Very High
Targeted Disruption 349 99.88 Very High Very High Very High
Disease 1788 99.84 Very High Very High Very High
Death 516 99.40 Very High Very High Very High
Apoptosis 219 98.96 Very High Very High Very High
Cv Unclassified Under Development 638 98.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During MPTP neurotoxicity, O2•?
Gene_expression (neurotoxicity) of MPTP associated with parkinson's disease and drug induced neurotoxicity
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.48 Pain Relevance 0.20
Although some microglia in the SN were activated in 24 h, we can conclude that DHE signals which we observed in 24 h after MPTP injection mostly reflected neuronal O2•?
Gene_expression (injection) of MPTP in neuronal associated with parkinson's disease and substantia nigra
2) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.40 Pain Relevance 0.19
For acute injection of MPTP, MPTP-HCl (20 mg/kg free base, SIGMA, USA) was administrated to mice intraperitoneally (i.p.) three times (2 h apart) and brains were extirpated under anesthesia 48 h after the last MPTP injection.
Gene_expression (injection) of MPTP in brains associated with parkinson's disease and anesthesia
3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.97 Pain Relevance 0.15
In contrast, in MPTP-treated mice, 4-HNE fluorescence was increased significantly 24 h after the last injection of MPTP.
Gene_expression (injection) of MPTP associated with parkinson's disease
4) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.69 Pain Relevance 0.12
Acute injection and continuous infusion of MPTP
Gene_expression (injection) of MPTP associated with parkinson's disease
5) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.95 Pain Relevance 0.14
For acute injection of MPTP, MPTP-HCl (20 mg/kg free base, SIGMA, USA) was administrated to mice intraperitoneally (i.p.) three times (2 h apart) and brains were extirpated under anesthesia 48 h after the last MPTP injection.
Gene_expression (injection) of MPTP in brains associated with parkinson's disease and anesthesia
6) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.00 Pain Relevance 0.17
For the continuous infusion of MPTP, an osmotic minipump (ALZET model 2004, USA) was transplanted subcutaneously, releasing either saline solution or MPTP solution at 45 mg/kg daily.
Gene_expression (infusion) of MPTP associated with parkinson's disease
7) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.99 Pain Relevance 0.20
For acute injection of MPTP, MPTP-HCl (20 mg/kg free base, SIGMA, USA) was administrated to mice intraperitoneally (i.p.) three times (2 h apart) and brains were extirpated under anesthesia 48 h after the last MPTP injection.
Gene_expression (injection) of MPTP in brains associated with parkinson's disease and anesthesia
8) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.97 Pain Relevance 0.15
Although continuous MPTP administration with an osmotic minipump mimics many features of the human disease [16], no significant effects in behavioral impairment except only open-field test showed significant change but not in other test such as rotarod test, tail suspension test, and ring test (data not shown).
Gene_expression (administration) of MPTP in tail associated with parkinson's disease and disease
9) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 1.60 Pain Relevance 0.11
Other behavioral tests, for example the rotarod test and tail suspension test, were also examined but no significant effects were observed following chronic MPTP infusion (data not shown).


Gene_expression (infusion) of MPTP in tail associated with parkinson's disease
10) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.58 Pain Relevance 0.08
The result showed that drinking H2/Mg water reduced the loss of dopaminergic neurons even after MPTP injection (Figure 3B, 3C; 16% & 17% recovery in drinking protocol shown as A&B, respectively).
Gene_expression (injection) of MPTP in dopaminergic neurons associated with parkinson's disease
11) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.86 Pain Relevance 0
During MPTP neurotoxicity, O2•?
Gene_expression (During) of MPTP associated with parkinson's disease and drug induced neurotoxicity
12) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.48 Pain Relevance 0.20
Valdecoxib reduces MPTP-induced locomotor activity deficits
Gene_expression (reduces) of MPTP associated with parkinson's disease and eae
13) Confidence 0.55 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.17 Pain Relevance 0.17
From these results we speculate that COX-2 may play some role in suppressing the chronic inflammation and microglial activation that is observed years after MPTP exposure [33-35].
Gene_expression (exposure) of MPTP associated with parkinson's disease and inflammation
14) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 1.10 Pain Relevance 0.17
We hypothesized that COX-2 inhibition or deficiency mediates effects involved in the neuroprotection of the SNpc dopaminergic neurons in MPTP-induced mouse parkinsonism.
Gene_expression (neuroprotection) of MPTP in dopaminergic neurons associated with parkinson's disease
15) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 1.14 Pain Relevance 0.03
The numbers of TH-positive neurons remaining in the SNpc after MPTP injection in the higher doses of valdecoxib-treated mice (30 and 50 mg/kg) are statistically higher than in the MPTP+vehicle group (#p < 0.05 and ###p < 0.001, Fig. 1B).
Gene_expression (injection) of MPTP in neurons associated with parkinson's disease
16) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.92 Pain Relevance 0.06
Our results differ from those of other investigators who have only reported behavioral testing one day post-MPTP injection or earlier [27,36-39].
Gene_expression (injection) of MPTP associated with parkinson's disease
17) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.72 Pain Relevance 0.08
The heterozygous mice have half the WT level of COX-2 [25], and this may explain the pharmacological benefits of reducing COX-2 activity because they exhibit less MPTP-induced Parkinson's disease-like pathology and symptoms as shown in this study.
Gene_expression (reducing) of MPTP associated with parkinson's disease and disease
18) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 1.05 Pain Relevance 0.03
Two weeks (day -14) before MPTP injection, Valdecoxib treatment was started.
Gene_expression (injection) of MPTP associated with parkinson's disease
19) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.55 Pain Relevance 0.11
This supports our hypothesis that inhibition of COX-2 expression during injury stimuli (MPTP) can reduce microglial activation, which may lead to secondary degeneration and progressive cell loss.
Gene_expression (expression) of MPTP associated with parkinson's disease and injury
20) Confidence 0.48 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.92 Pain Relevance 0.08

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