INT161118

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.46
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Cth) nucleus (Cth) cellular_component (Cth)
cellular amino acid metabolic process (Cth) cytoplasm (Cth)
Anatomy Link Frequency
neural 1
Cth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 4 99.98 Very High Very High Very High
chemokine 10 94.16 High High
adenocard 2 80.60 Quite High
headache 2 75.00 Quite High
alcohol 22 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 3 99.98 Very High Very High Very High
Adhesions 8 99.56 Very High Very High Very High
Stress 8 98.86 Very High Very High Very High
Low Back Pain 1 81.12 Quite High
Congenital Anomalies 1 79.28 Quite High
Headache 1 75.00 Quite High
Cancer 8 71.20 Quite High
Body Weight 6 5.00 Very Low Very Low Very Low
Liver Disease 4 5.00 Very Low Very Low Very Low
Fatty Liver 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose a neural model whereby stress acts supra-spinally to aggravate already increased pain sensitivity in CTH sufferers.
Regulation (sensitivity) of CTH in neural associated with stress and pain
1) Confidence 0.27 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 19541431 Disease Relevance 0.93 Pain Relevance 0.40
Cystathionase, which generates cysteine and aldehyde dehydrogenase, which oxidizes acetaldehyde, were both down regulated (Table 3) as were many other enzymes in the metabolic pathway (Fig. 3).
Regulation (regulated) of Cystathionase
2) Confidence 0.03 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.53 Pain Relevance 0.32

General Comments

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