INT161121

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.99
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Erap1) extracellular region (Erap1) endoplasmic reticulum (Erap1)
cytoplasm (Erap1)
Erap1 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 22 99.76 Very High Very High Very High
spondylitis 1 92.72 High High
cytokine 3 76.72 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 23 99.76 Very High Very High Very High
Disease 2 90.84 High High
Genetic Predisposition To Disease 1 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERAP1 was found to be associated with ankylosing spondylitis (AS) in a genome-wide association study of nonsynonymous single nucleotide polymorphisms, and this association has been confirmed in several studies.
ERAP1 Binding (associated) of associated with spinal inflammation
1) Confidence 0.48 Published 2010 Journal Nat Rev Rheumatol Section Abstract Doc Link 20531381 Disease Relevance 0.35 Pain Relevance 0.38
Recent studies including linkage analyses as well as candidate gene and, most recently, genome-wide association studies indicate significant associations of the interleukin-1 gene cluster, interleukin-23 receptor and ARTS1 genes as well as other possible loci with AS.
ARTS1 Binding (associations) of associated with spinal inflammation
2) Confidence 0.47 Published 2009 Journal Joint Bone Spine Section Abstract Doc Link 19541528 Disease Relevance 0.88 Pain Relevance 0.65
An ERAP1/ERAP2 haplotype has also been reported to be associated with familial AS.
ERAP2 Binding (associated) of associated with spinal inflammation
3) Confidence 0.37 Published 2010 Journal Nat Rev Rheumatol Section Abstract Doc Link 20531381 Disease Relevance 0.38 Pain Relevance 0.48
An ERAP1/ERAP2 haplotype has also been reported to be associated with familial AS.
ERAP1 Binding (associated) of associated with spinal inflammation
4) Confidence 0.37 Published 2010 Journal Nat Rev Rheumatol Section Abstract Doc Link 20531381 Disease Relevance 0.38 Pain Relevance 0.49

General Comments

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