INT161164

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.62
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prkcg, Creb1) nucleoplasm (Creb1) mitochondrion (Creb1)
intracellular (Prkcg) DNA binding (Creb1) response to stress (Prkcg)
Anatomy Link Frequency
nucleus 4
spinal cord 2
dorsal horn 2
Prkcg (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 44 100.00 Very High Very High Very High
withdrawal 18 99.98 Very High Very High Very High
Morphine 18 99.76 Very High Very High Very High
narcan 4 99.60 Very High Very High Very High
Dorsal horn 2 99.42 Very High Very High Very High
Spinal cord 30 99.40 Very High Very High Very High
qutenza 58 97.82 Very High Very High Very High
long-term potentiation 10 95.88 Very High Very High Very High
central sensitization 26 93.84 High High
intrathecal 12 77.96 Quite High
Disease Link Frequency Relevance Heat
Stress 4 85.20 High High
Nociception 34 85.12 High High
Hypersensitivity 2 68.16 Quite High
Pain 4 56.48 Quite High
Attention Deficit Hyperactivity Disorder 2 33.24 Quite Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine withdrawal regulates phosphorylation of cAMP response element binding protein (CREB) through PKC in the nucleus tractus solitarius-A2 catecholaminergic neurons.
PKC Regulation (regulates) of Phosphorylation (phosphorylation) of cAMP response element binding protein in nucleus associated with withdrawal and morphine
1) Confidence 0.41 Published 2009 Journal J. Neurochem. Section Title Doc Link 19545278 Disease Relevance 0.15 Pain Relevance 0.69
In summary, the findings from our investigation provide strong evidence that MAP kinase, PKA and PKC participate in the regulation of CREB phosphorylation status in the spinal cord following peripheral noxious stimulation.
PKC Regulation (regulation) of Phosphorylation (phosphorylation) of CREB in spinal cord associated with kinase c and spinal cord
2) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.23 Pain Relevance 0.91
The major findings in the current study demonstrated that intradermal capsaicin injection causes an increase in Ser-133 CREB phosphorylation in the dorsal horn and that the enhancement of CREB phosphorylation is regulated by the activity of MAP kinase, PKA and PKC.
PKC Regulation (regulated) of Phosphorylation (phosphorylation) of CREB in dorsal horn associated with kinase c, qutenza and dorsal horn
3) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.09 Pain Relevance 0.82
Morphine withdrawal regulates phosphorylation of cAMP response element binding protein (CREB) through PKC in the nucleus tractus solitarius-A2 catecholaminergic neurons.
PKC Regulation (through) of Phosphorylation (phosphorylation) of cAMP response element binding protein in nucleus associated with withdrawal and morphine
4) Confidence 0.18 Published 2009 Journal J. Neurochem. Section Title Doc Link 19545278 Disease Relevance 0.15 Pain Relevance 0.69

General Comments

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